Sleep Duration and All-Cause Mortality: A Systematic Review and Meta-Analysis of Prospective Studies
TLDR
Both short and long duration of sleep are significant predictors of death in prospective population studies as well as sensitivity analyses and publication bias are assessed.Abstract:
Background: Increasing evidence suggests an association between both short and long duration of habitual sleep with adverse health outcomes.
Objectives: To assess whether the population longitudinal evidence supports the presence of a relationship between duration of sleep and all-cause mortality, to investigate both short and long sleep duration and to obtain an estimate of the risk.
Methods: We performed a systematic search of publications using MEDLINE (1966-2009), EMBASE (from 1980), the Cochrane Library, and manual searches without language restrictions. We included studies if they were prospective, had follow-up >3 years, had duration of sleep at baseline, and all-cause mortality prospectively. We extracted relative risks (RR) and 95% confidence intervals (CI) and pooled them using a random effect model. We carried out sensitivity analyses and assessed heterogeneity and publication bias.
Results: Overall, the 16 studies analyzed provided 27 independent cohort samples. They included 1,382,999 male and female participants (follow-up range 4 to 25 years), and 112,566 deaths. Sleep duration was assessed by questionnaire and outcome through death certification. In the pooled analysis, short duration of sleep was associated with a greater risk of death (RR: 1.12; 95% CI 1.06 to 1.18; P <0.01) with no evidence of publication bias (P = 0.74) but heterogeneity between studies (P = 0.02). Long duration of sleep was also associated with a greater risk of death (1.30; [1.22 to 1.38]; P < 0.0001) with no evidence of publication bias (P = 0.18) but significant heterogeneity between studies (P < 0.0001).
Conclusion: Both short and long duration of sleep are significant predictors of death in prospective population studies.read more
Citations
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Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies
Francesco P. Cappuccio,Daniel D. Cooper,Lanfranco D'Elia,Pasquale Strazzullo,Michelle A. Miller +4 more
TL;DR: Both short and long duration of sleep are predictors, or markers, of cardiovascular outcomes of coronary heart disease and total cardiovascular disease.
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Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation
TL;DR: Global evidence linking sleep disturbance, sleep duration, and inflammation in adult humans is assessed and sleep disturbance and long sleep duration are associated with increases in markers of systemic inflammation.
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Short sleep duration and health outcomes: a systematic review, meta-analysis, and meta-regression.
TL;DR: The effectiveness of psychosocial interventions to improve sleep on reducing these health outcomes in general community settings is examined and a linear association between a statistically significant increase in mortality and sleep duration at less than six hours is found.
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Combined Effects of Time Spent in Physical Activity, Sedentary Behaviors and Sleep on Obesity and Cardio-Metabolic Health Markers: A Novel Compositional Data Analysis Approach
TL;DR: Time spent in MVPA is an important target for intervention and preventing transfer of time from LIPA to SB might lessen the negative effects of physical inactivity, so time spent in each of these behaviors are codependent.
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