Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases.
TLDR
While EpFAs demonstrate activity against inflammatory pain, interestingly, this action extends to blocking chronic neuropathic pain as well, which greatly contributes to the overall understanding of their role in the inflammatory response.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2017-12-01 and is currently open access. It has received 181 citations till now. The article focuses on the topics: Epoxide hydrolase 2 & Eicosanoid.read more
Citations
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Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases.
TL;DR: Based on preclinical studies, these omega‐3 epoxyeicosanoids display cardioprotective, vasodilatory, anti‐inflammatory, and anti‐allergic properties that contribute to the beneficial effects of n‐3 LC‐PUFAs in diverse disease conditions ranging from cardiac disease, bronchial disorders, and intraocular neovascularization, to allergic intestinal inflammation and inflammatory pain.
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Eicosanoids: The Overlooked Storm in Coronavirus Disease 2019 (COVID-19)?
TL;DR: The predominant role of eicosanoids in regulating the inflammatory cascade is discussed, the potential application of sEH inhibitors in alleviating COVID-19 symptoms is proposed and the host-protective action of omega-3 fatty acid-derived epoxyeicOSanoids and specialized proresolving mediators in regulating anti-inflammation and antiviral response is discussed.
Journal ArticleDOI
Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.
Qian Ren,Min Ma,Jun Yang,Risa Nonaka,Akihiro Yamaguchi,Kei-Ichi Ishikawa,Kenta Kobayashi,Shigeo Murayama,Sung Hee Hwang,Shinji Saiki,Wado Akamatsu,Nobutaka Hattori,Bruce D. Hammock,Kenji Hashimoto +13 more
TL;DR: It is found that MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced neurotoxicity in the mouse striatum was attenuated by subsequent repeated administration of TPPU, a potent sEH inhibitor.
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Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase
Yaoyu Pu,Jun Yang,Lijia Chang,Youge Qu,Siming Wang,Kai Zhang,Zhongwei Xiong,Jiancheng Zhang,Yunfei Tan,Xingming Wang,Yuko Fujita,Tamaki Ishima,Debin Wang,Sung Hee Hwang,Bruce D. Hammock,Kenji Hashimoto +15 more
TL;DR: It is suggested that maternal exposure to high levels of glyphosate causes ASD-like behavioral abnormalities and abnormal composition of gut microbiota in juvenile offspring, and that increased activity of sEH might play a role in ASD- like behaviors in offspring after maternal glyphosate exposure.
References
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TL;DR: A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve and the postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain were produced.
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Parkinson's disease: Mechanisms and models
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Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
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