Journal ArticleDOI
Specific IgE antibodies to platinum salts in sensitized workers
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A RAST has been developed for the measurement of IgE antibodies specific to platinum chloride complexes in sensitized workers by reacting with ammonium tetrachloroplatinite (II) (NH4)2PtCl4 to find a conjugate more suitable for the RAST.Abstract:
A RAST has been developed for the measurement of IgE antibodies specific to platinum chloride complexes in sensitized workers. Human serum albumin covalently linked to Sepharose beads by the cyanogen bromide method was reacted with ammonium tetrachloroplatinite (II) (NH4)2PtCl4. This conjugate was more suitable for the RAST, than conjugates of HSA and the platinum salt prepared in solution and then linked to the activated Sepharose, showing better sensitivity and giving lower levels of non-specific uptake of IgE from sera of non-exposed subjects with high total levels of IgE, e.g. allergic bronchopulmonary aspergillotics.read more
Citations
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Association of asthma with serum IgE levels and skin-test reactivity to allergens.
TL;DR: It is concluded that asthma is almost always associated with some type of IgE-related reaction and therefore has an allergic basis, although not all the allergic stimuli that cause asthma appear to have been included in the battery of common aeroallergens the authors used to assess atopic status.
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Platinum group elements in the environment and their health risk.
TL;DR: There is a need to study the effect on human health of long-term chronic exposure to low levels of Pt compounds, as well as the toxicity of biologically available anthropogenic Pt, in diverse environmental matrices.
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Late asthmatic responses.
Journal ArticleDOI
Clinical Features of Hypersensitivity Reactions to Carboplatin
Maurie Markman,Alexander W. Kennedy,Kenneth Webster,Paul Elson,Gertrude Peterson,Barbara Kulp,Jerome L. Belinson +6 more
TL;DR: The clinical features of carboplatin hypersensitivity reactions develop in patients who have been extensively pretreated with the agent, but they are sufficiently different from those noted after the administration of paclitaxel that it should not be difficult to distinguish between reactions to the two agents.
Journal ArticleDOI
Antibodies against metal chelates
Dayton T. Reardan,Claude F. Meares,David A. Goodwin,David A. Goodwin,Maureen McTigue,Maureen McTigue,Gary S. David,Mary R. Stone,Julia P. Leung,Richard M. Bartholomew,James M. Frincke +10 more
TL;DR: These antibodies show a remarkable preference for indium chelates; changing to another metal such as scandium or gallium can decrease the antibody-binding constant by more than three orders of magnitude, which introduces a new degree of control over the biological distributions of chelated radionuclides.
References
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Journal ArticleDOI
Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity
W M Hunter,F. C. Greenwood +1 more
TL;DR: Current procedures for the immunological assay of protein hormones in human plasma require the routine preparation of hormones labelled with iodine-131 of high specific activity, and this work demonstrates the importance of knowing the carrier and removal status of iodine.
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A simplified method for cyanogen bromide activation of agarose for affinity chromatography
TL;DR: Agarose can be activated by adding cyanogen bromide, dissolved in acetonitrile, to beads suspended in a solution of sodium carbonate, and the necessity for manual titration and the use of a pH meter are eliminated.
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Trimellitic anhydride-induced airway syndromes: Clinical and immunologic studies
C.Raymond Zeiss,Roy Patterson,Jacob J. Pruzansky,Michael M. Miller,Michael Rosenberg,Levitz D +5 more
TL;DR: A spectrum of respiratory symptoms in workers exposed to trimellitic anhydride, a biologically reactive chemical used in the plastics industry, is described, including asthma and rhinitis of the immediate type, late onset asthma with systemic symptoms, and airway irritation.
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Immediate (type I) allergic responses to platinum compounds.
TL;DR: The results show that the allergy‐eliciting compounds are confined to a very small group of ionic complexes containing reactive halogen ligands and neutral complexes and those containing more strongly bound ligands are totally inactive.
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Asthma Caused by the Complex Salts of Platinum
TL;DR: Up to 1915 almost the whole of the world's platinum production came from alluvial deposits in Russia and Colombia, but in more recent years other sources of the platinum metals have become available.