Journal ArticleDOI
Speech metrics, general disability, brain imaging and quality of life in multiple sclerosis.
Gustavo Noffs,Gustavo Noffs,Frederique M.C. Boonstra,Thushara Perera,Thushara Perera,Helmut Butzkueven,Scott C Kolbe,Fernanda Maldonado,L Euardo Cofre Lizama,L Euardo Cofre Lizama,L Euardo Cofre Lizama,Mary P. Galea,Mary P. Galea,Jim Stankovich,Andrew Evans,Andrew Evans,A. Van der Walt,A. Van der Walt,A. Van der Walt,Adam P. Vogel +19 more
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TLDR
The relationship between disease severity and speech metrics through perceptual (listener based) and objective acoustic analysis and deviations of acoustic metrics in people with no perceivable dysarthria are characterized.Abstract:
BACKGROUND AND PURPOSE: Objective measurement of speech has shown promising results to monitor disease state in multiple sclerosis. In this study, we characterize the relationship between disease severity and speech metrics through perceptual (listener based) and objective acoustic analysis. We further look at deviations of acoustic metrics in people with no perceivable dysarthria. METHODS: Correlations and regression were calculated between speech measurements and disability scores, brain volume, lesion load and quality of life. Speech measurements were further compared between three subgroups of increasing overall neurological disability: mild (as rated by the Expanded Disability Status Scale ≤2.5), moderate (≥3 and ≤5.5) and severe (≥6). RESULTS: Clinical speech impairment occurred majorly in people with severe disability. An experimental acoustic composite score differentiated mild from moderate (P < 0.001) and moderate from severe subgroups (P = 0.003), and correlated with overall neurological disability (r = 0.6, P < 0.001), quality of life (r = 0.5, P < 0.001), white matter volume (r = 0.3, P = 0.007) and lesion load (r = 0.3, P = 0.008). Acoustic metrics also correlated with disability scores in people with no perceivable dysarthria. CONCLUSIONS: Acoustic analysis offers a valuable insight into the development of speech impairment in multiple sclerosis. These results highlight the potential of automated analysis of speech to assist in monitoring disease progression and treatment response.read more
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Oral and Laryngeal Diadochokinesis Across the Life Span: A Scoping Review of Methods, Reference Data, and Clinical Applications
TL;DR: A scoping review of research on oral and laryngeal diadochokinesis (DDK) in children and adults, either typically developing/developed or with a clinical diagnosis was conducted by as discussed by the authors .
Journal ArticleDOI
Assessing clinical utility of machine learning and artificial intelligence approaches to analyze speech recordings in multiple sclerosis: A pilot study
TL;DR: In this article , a corpus of 65 MS-positive and 66 healthy individuals reading the same text aloud was used for targeted acoustic feature extraction utilizing automatic phoneme segmentation, and a series of binary classification models were trained, tuned, and evaluated regarding their Accuracy and area-under-the-curve.
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Assessing clinical utility of Machine Learning and Artificial Intelligence approaches to analyze speech recordings in Multiple Sclerosis: A Pilot Study.
Emil Svoboda,Tomas Boril,Jan Rusz,Tereza Tykalová,Dana Horakova,Charles R. G. Guttman,Krastan B. Blagoev,Hiroto Hatabu,Vlad I. Valtchinov +8 more
TL;DR: In this article, a corpus of 65 MS-positive and 66 healthy individuals reading the same text aloud was used for targeted acoustic feature extraction utilizing automatic phoneme segmentation, and a series of binary classification models were trained, tuned, and evaluated regarding their Accuracy and area-under-curve.
Journal ArticleDOI
Speech Pathology-Specific Questionnaire for Persons with Multiple Sclerosis (SMS): adaptation, validation and preliminary assessment of the diagnostic potential.
Joanna Morawska,Ewa Niebudek-Bogusz,Mariusz Stasiołek,Mariola Świderek-Matysiak,Wioletta Pietruszewska +4 more
TL;DR: In this paper, an adaptation and validation of the Speech Pathology-Specific Questionnaire for Persons with Multiple Sclerosis (SMS) into the Polish language to quantify important speech-related changes and to improve individual tailoring of therapeutic activities is presented.
Journal ArticleDOI
Adults with a history of recreational cannabis use have altered speech production.
Adam P. Vogel,Adam P. Vogel,Verity Pearson-Dennett,Michelle Magee,Robert A Wilcox,Robert A Wilcox,Robert A Wilcox,Adrian Esterman,Adrian Esterman,Dominic Thewlis,Jason M. White,Gabrielle Todd +11 more
TL;DR: In this paper, the authors investigate speech in individuals with a history of recreational cannabis use compared to non-drug-using healthy controls and find that subtle differences in speech timing, vocal effort, and voice quality may exist between cannabis and control groups.
References
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Journal ArticleDOI
Rating neurologic impairment in multiple sclerosis An expanded disability status scale (EDSS)
TL;DR: A new Expanded Disability Status Scale (EDSS) is presented, with each of the former steps (1,2,3 … 9) now divided into two (1.0, 1.5, 2.0 … 9).
Journal ArticleDOI
The control of the false discovery rate in multiple testing under dependency
Yoav Benjamini,Daniel Yekutieli +1 more
TL;DR: In this paper, it was shown that a simple FDR controlling procedure for independent test statistics can also control the false discovery rate when test statistics have positive regression dependency on each of the test statistics corresponding to the true null hypotheses.
Journal ArticleDOI
The ASA's Statement on p-Values: Context, Process, and Purpose
TL;DR: The American Statistical Association (ASA) released a policy statement on p-values and statistical significance in 2015 as discussed by the authors, which was based on a discussion with the ASA Board of Trustees and concerned with reproducibility and replicability of scientific conclusions.
Journal ArticleDOI
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Alan J. Thompson,Brenda Banwell,Frederik Barkhof,Frederik Barkhof,William M. Carroll,Timothy Coetzee,Giancarlo Comi,Jorge Correale,Franz Fazekas,Massimo Filippi,Mark S. Freedman,Kazuo Fujihara,Steven L. Galetta,Hans-Peter Hartung,Ludwig Kappos,Fred D. Lublin,Ruth Ann Marrie,Aaron E. Miller,David Miller,Xavier Montalban,Xavier Montalban,Ellen M. Mowry,Per Soelberg Sørensen,Mar Tintoré,Anthony Traboulsee,Maria Trojano,Bernard M. J. Uitdehaag,Sandra Vukusic,Sandra Vukusic,Emmanuelle Waubant,Brian G. Weinshenker,Stephen C. Reingold,Jeffrey A. Cohen +32 more
TL;DR: The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation.