B
Bernard M. J. Uitdehaag
Researcher at VU University Amsterdam
Publications - 328
Citations - 21647
Bernard M. J. Uitdehaag is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Multiple sclerosis & Expanded Disability Status Scale. The author has an hindex of 65, co-authored 295 publications receiving 17677 citations. Previous affiliations of Bernard M. J. Uitdehaag include VU University Medical Center & University of Amsterdam.
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Journal ArticleDOI
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Alan J. Thompson,Brenda Banwell,Frederik Barkhof,Frederik Barkhof,William M. Carroll,Timothy Coetzee,Giancarlo Comi,Jorge Correale,Franz Fazekas,Massimo Filippi,Mark S. Freedman,Kazuo Fujihara,Steven L. Galetta,Hans-Peter Hartung,Ludwig Kappos,Fred D. Lublin,Ruth Ann Marrie,Aaron E. Miller,David Miller,Xavier Montalban,Xavier Montalban,Ellen M. Mowry,Per Soelberg Sørensen,Mar Tintoré,Anthony Traboulsee,Maria Trojano,Bernard M. J. Uitdehaag,Sandra Vukusic,Sandra Vukusic,Emmanuelle Waubant,Brian G. Weinshenker,Stephen C. Reingold,Jeffrey A. Cohen +32 more
TL;DR: The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation.
Journal ArticleDOI
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
Philip L. De Jager,Philip L. De Jager,Xiaoming Jia,Joanne Wang,Paul I.W. de Bakker,Linda Ottoboni,Linda Ottoboni,Neelum T. Aggarwal,Laura Piccio,Soumya Raychaudhuri,Dong Tran,Cristin Aubin,Rebeccah Briskin,Susan Romano,Sergio E. Baranzini,Jacob L. McCauley,Margaret A. Pericak-Vance,Jonathan L. Haines,Rachel A. Gibson,Yvonne Naeglin,Bernard M. J. Uitdehaag,Paul M. Matthews,Ludwig Kappos,Chris H. Polman,Wendy L. McArdle,David P. Strachan,Denis A. Evans,Anne H. Cross,Mark J. Daly,Alastair Compston,Stephen Sawcer,Howard L. Weiner,Stephen L. Hauser,David A. Hafler,David A. Hafler,Jorge R. Oksenberg +35 more
TL;DR: It is reported that the susceptibility allele near IRF8, which encodes a transcription factor known to function in type I Interferon signaling, is associated with higher mRNA expression of interferon-response pathway genes in subjects with MS.
Journal Article
PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS
Gordon S. Francis,R Hughes,J King,P Mitchell,J Joubert,J McLeod,G Parker,John D. Pollard,Sindic Cjm.,T Duprez,R Medaer,J Broeckx,E Vanroose,H Carton,G Wilms,George P.A. Rice,George C. Ebers,D H Lee,Matthew L. Freedman,R. F. Nelson,H Rabinovitch,S Christie,L Avruch,Joel Oger,Donald W. Paty,D Li,J Wikstrom,Salonen Olm.,M Panelius,J.P. Eralinna,P Sonninen,P Rieckmann,D Hahn,P Flachenecker,H.-P. Hartung,Bernard M. J. Uitdehaag,F W Bertelsmann,Frederik Barkhof,O R Hommes,Jongen Pjh.,P.A. van Doorn,Tanghe Hlg.,Magnhild Sandberg-Wollheim,E M Larsson,M Lonntoft,S Sallerfors,Ludwig Kappos,C Lienert,E W Radu,M Chofflon,S Roth,V Castillo,A F Schwieger,Hughes Rac.,A M Clews,J B Bingham,D Barnes,A G Clifton,N Stoy,D Bates,A Coulthard,L D Blumhardt,S M Evans,T Jaspan,J Palace,J M Newsom-Davis,James V. Byrne,G Quaghebeur,Li Dkb.,G J Zhao,A Riddehough,B Rhodes,Grp Prismss.,Anal Ubcmsmri. +73 more
TL;DR: Clinical and MRI benefit continued for both doses up to 4 years, with evidence of dose response, and outcomes were consistently better for patients treated for 4 years than for patients in crossover groups.
Journal ArticleDOI
Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages.
TL;DR: Results show that the M psi within the CNS play an important role in the pathogenesis of EAE, and injections of mannosylated liposomes containing dichloromethylene diphosphonate injected intravenously eliminate M psi in spleen and liver markedly suppressed the expression of clinical signs of Eae.
Journal ArticleDOI
Intracortical Lesions in Multiple Sclerosis: Improved Detection with 3D Double Inversion-Recovery MR Imaging
Jeroen J. G. Geurts,Petra J. W. Pouwels,Bernard M. J. Uitdehaag,Chris H. Polman,Frederik Barkhof,Jonas A. Castelijns +5 more
TL;DR: In this paper, the depiction of intracortical lesions by using multislab three-dimensional (3D) double inversion-recovery (DIR), multiislab 3D fluid-attenuated inversion recovery (FLAIR), and T2-weighted spin-echo (SE) imaging in patients with multiple sclerosis was compared.