Journal ArticleDOI
Sperm DNA damage assessment: a test whose time has come
TLDR
Evidence is provided that integrity of sperm DNA influences a couple's fertility and helps predict the chances of pregnancy and its successful outcome.About:
This article is published in Fertility and Sterility.The article was published on 2005-10-01. It has received 186 citations till now.read more
Citations
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Journal ArticleDOI
The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy
TL;DR: Adequately powered, placebo-controlled comprehensive clinical trials are now required to establish a clear role for antioxidants in the prevention of oxidative stress in the male germ line, such that the clinical utility of this form of therapy becomes established once and for all.
Journal ArticleDOI
Insulin dependant diabetes mellitus: implications for male reproductive function
I.M. Agbaje,Deirdre Rogers,Carmel M. McVicar,Neil McClure,A.B. Atkinson,Con Mallidis,Sheena E.M. Lewis +6 more
TL;DR: Diabetes is associated with increased sperm nuclear and mtDNA damage that may impair the reproductive capability of men attending fertility clinics and this work aims to address this concern.
Journal ArticleDOI
Do sperm DNA integrity tests predict pregnancy with in vitro fertilization
TL;DR: The small but statistically significant association between sperm DNA integrity test results and pregnancy in IVF and ICSI cycles is not strong enough to provide a clinical indication for routine use of these tests in infertility evaluation of men.
Journal ArticleDOI
Sperm chromatin structure assay parameters are not related to fertilization rates, embryo quality, and pregnancy rates in in vitro fertilization and intracytoplasmic sperm injection, but might be related to spontaneous abortion rates
Ming-Huei Lin,Robert Kuo-Kuang Lee,Robert Kuo-Kuang Lee,Sheng-Hsiang Li,Sheng-Hsiang Li,Chung-Hao Lu,Fang-Ju Sun,Yuh-Ming Hwu,Yuh-Ming Hwu +8 more
TL;DR: Neither DFI nor HDS scores can provide independent information about embryo quality, fertilization, and PRs for infertility patients undergoing ART, and the potential adverse effect of sperm DNA damage on the quality of postimplantation embryo and spontaneous abortion should be a concern.
Journal ArticleDOI
Early oxidative stress in testis and epididymal sperm in streptozotocin-induced diabetic mice: its progression and genotoxic consequences.
B. Shrilatha,Muralidhara +1 more
TL;DR: Based on the occurrence of oxidative impairments in STZ-treated mice both during both early and progressive phase, it is hypothesized that oxidative stress mechanisms may be wholly or in part contribute towards the development of testicular dysfunction and degeneration under situations of experimentally induced diabetes in animal models.
References
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Journal ArticleDOI
Role of reactive oxygen species in the pathophysiology of human reproduction
TL;DR: High levels of ROS are detrimental to the fertility potential both in natural and assisted conception states.
Journal ArticleDOI
Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic
Donald P. Evenson,Lorna K. Jost,D Marshall,M J Zinaman,E D Clegg,K Purvis,P. De Angelis,O P Claussen +7 more
TL;DR: Based on logistic regression, spermatozoa with denatured DNA (cells outside the main population, COMP alpha t) were the best predictor for whether a couple would not achieve pregnancy.
Journal ArticleDOI
Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques.
Journal ArticleDOI
Role of sperm chromatin abnormalities and DNA damage in male infertility
Ashok Agarwal,Tamer M. Said +1 more
TL;DR: Screening for sperm DNA damage may provide useful information in cases of male idiopathic infertility and in those men pursuing assisted reproduction, and treatment should include methods for prevention of spermDNA damage.
Journal ArticleDOI
Sperm chromatin damage impairs human fertility
Marcello Spanò,Jens Peter Bonde,Henrik Hjøllund,Henrik A Kolstad,Eugenia Cordelli,Giorgio Leter +5 more
TL;DR: The SCSA emerged as a predictor of the probability to conceive in this population-based study and Optimal sperm chromatin packaging seems necessary for full expression of the male fertility potential.
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Role of sperm chromatin abnormalities and DNA damage in male infertility
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