Open AccessJournal Article
Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
Yali Jia,Ou Tan,Jason Tokayer,Benjamin Potsaid,Y. Wang,Jonathan J. Liu,Martin F. Kraus,Hrebesh M. Subhash,James G. Fujimoto,Joachim Hornegger,David Huang +10 more
TLDR
In this paper, a split-spectrum amplitude-decorrelation angiography (SSADA) was proposed to improve the signal-to-noise ratio (SNR) of flow detection.Abstract:
Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction. To overcome this limitation, we developed split-spectrum amplitude-decorrelation angiography (SSADA) to improve the signal-to-noise ratio (SNR) of flow detection. The full OCT spectrum was split into several narrower bands. Inter-B-scan decorrelation was computed using the spectral bands separately and then averaged. The SSADA algorithm was tested on in vivo images of the human macula and optic nerve head. It significantly improved both SNR for flow detection and connectivity of microvascular network when compared to other amplitude-decorrelation algorithms.read more
Citations
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Journal ArticleDOI
Optical coherence tomography angiography.
TL;DR: The integration of OCTA in multimodal imaging in the evaluation of retinal vascular occlusive diseases, diabetic retinopathy, uveitis, inherited diseases, age-related macular degeneration, and disorders of the optic nerve is presented.
Journal ArticleDOI
Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications.
Amir H. Kashani,Chieh-Li Chen,Jin Kyu Gahm,Fang Zheng,Grace M. Richter,Philip J. Rosenfeld,Yonggang Shi,Ruikang K. Wang +7 more
TL;DR: The methods used to create OCTA images, the practical applications of OCTA in light of invasive dye‐imaging studies (e.g. fluorescein angiography) and clinical studies demonstrating the utility of OCT a for research and clinical practice are discussed.
Image artifacts in optical coherence tomography angiography
TL;DR: In this paper, the authors describe image artifacts of OCT angiography and their underlying causative mechanisms, and establish a common vocabulary for the artifacts observed, and provide a review of the methods by which OCT images are acquired, generated and displayed.
Journal ArticleDOI
Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye
Yali Jia,Steven T. Bailey,Thomas S. Hwang,Scott M. McClintic,Simon S. Gao,Mark E. Pennesi,Christina J. Flaxel,Andreas K. Lauer,David J. Wilson,Joachim Hornegger,James G. Fujimoto,David Huang +11 more
TL;DR: OCTAngiography shows promise as a noninvasive alternative to dye-based angiography for highly detailed, in vivo, 3D, quantitative evaluation of retinal vascular abnormalities.
Journal ArticleDOI
Detailed Vascular Anatomy of the Human Retina by Projection-Resolved Optical Coherence Tomography Angiography
J. P. Campbell,Miao Zhang,Thomas S. Hwang,Steven T. Bailey,David J. Wilson,Yali Jia,David Huang +6 more
TL;DR: This investigation in normal human volunteers revealed the presence of 2 to 4 distinct vascular plexuses in the retina, depending on location relative to the optic disc and fovea, and proposes an improved system of nomenclature and segmentation boundaries for detailed 3-dimensional retinal vascular anatomy by OCTA.
References
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Optical Coherence Tomography
TL;DR: The optical coherence tomograph is a new, noninvasive technical device that can obtain cross-sectional, high-resolution images-optical coherencetomographs (OCT)-of the retina that permits an accurate evaluation of various macular and chorioretinal pathologies and the early detection of glaucomatous damage.
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Sensitivity advantage of swept source and Fourier domain optical coherence tomography
TL;DR: Results are presented which demonstrate the superior sensitivity of swept source (SS) and Fourier domain (FD) optical coherence tomography (OCT) techniques over the conventional time domain (TD) approach.
Journal ArticleDOI
Performance of fourier domain vs. time domain optical coherence tomography.
TL;DR: It is shown that FDOCT systems have a large sensitivity advantage and allow for sensitivities well above 80dB, even in situations with low light levels and high speed detection.
Journal ArticleDOI
Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography
Johannes F. de Boer,Barry Cense,B. Hyle Park,Mark C. Pierce,Guillermo J. Tearney,Brett E. Bouma +5 more
TL;DR: A signal-to-noise ratio (SNR) analysis is presented for optical coherence tomography (OCT) signals in which time-domain performance is compared with that of the spectral domain.
Journal Article
Measurement of intraocular distances by backscattering spectral interferometry
TL;DR: In this article, the diffraction tomography theorem is adapted to one-dimensional length measurement and the resulting spectral interferometry technique is described and the first length measurements using this technique on a model eye and on a human eye in vivo are presented.