Stimulation of motor tracts in motor neuron disease.
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The muscle responses evoked by cortical and cervical stimulation in 11 patients with motor neuron disease were studied and electrophysiological techniques are helpful in estimating the site of motor involvement in motor neurons disease.Abstract:
The muscle responses evoked by cortical and cervical stimulation in 11 patients with motor neuron disease were studied. The muscle potential in the abductor pollicis brevis, evoked by median nerve stimulation and the somatosensory potential evoked by wrist stimulation were also studied. In eight of 11 patients there was absence or increased central delay of the responses evoked by cortical stimulation. In four patients muscle responses on cervical stimulation and muscle action potentials on median nerve stimulation were also altered, indicating peripheral abnormalities. Somatosensory responses evoked by wrist stimulation were normal. Electrophysiological techniques are helpful in estimating the site of motor involvement in motor neuron disease.read more
Citations
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Stimulation of the human motor cortex through the scalp.
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Mapping of Motor Cortical Reorganization After Stroke A Brain Stimulation Study With Focal Magnetic Pulses
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Post-stroke reorganization of brain motor output to the hand: a 2–4 month follow-up with focal magnetic transcranial stimulation
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Changes in corticomotor representations induced by prolonged peripheral nerve stimulation in humans.
TL;DR: Prolonged afferent stimulation induces an increase in excitability of the corticospinal projection which is accompanied by a significant shift in the centre of gravity of the stimulated muscles which is proposed is evidence of a non-uniform expansion in their cortical representation.
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Follow-up of interhemispheric differences of motor evoked potentials from the 'affected' and 'unaffected' hemispheres in human stroke
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References
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Journal ArticleDOI
Stimulation of the cerebral cortex in the intact human subject
P. A. Merton,H. B. Morton +1 more
TL;DR: It has now been found that, on stimulating muscles in the human hand without any special preparation of the skin, the effective resistance fell to low values if brief but very high voltage shocks were used.
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Scope of a technique for electrical stimulation of human brain, spinal cord, and muscle.
TL;DR: Brief high-voltage electrical shocks from a special low-output-resistance stimulator, delivered through electrodes on the skin, can excite human muscle directly (not by way of the nerves) and can also excite the motor cortex, the visual cortex, and the spinal cord.
Journal ArticleDOI
Motor evoked potentials from transcranial stimulation of the motor cortex in humans.
TL;DR: This test offers an electrical assessment of the motor system that can be useful in experimental work on spinal cord and brain function and has potential clinical applicability in humans.
Journal ArticleDOI
Morphometric and biochemical studies of peripheral nerves in amyotrophic lateral sclerosis
TL;DR: It is shown that in amyotrophic lateral sclerosis a small degree of dying‐back change and of distal axonal atrophy is superimposed on the degeneration of motor neuron cell bodies, and that the disease effects spread beyond the motor neurons.
Journal ArticleDOI
Peripheral nerve conduction in diabetic neuropathy.
R. W. Gilliatt,R. G. Willison +1 more
TL;DR: In this paper, a small number of diabetic patients who have been extensively investigated, with the object of relating the electrical findings to the particular clinical features of individual cases, were selected.