Streptococcal toxic shock syndrome caused by Streptococcus suis serotype 2.
Jiaqi Tang,Changjun Wang,Youjun Feng,Weizhong Yang,Huaidong Song,Huaidong Song,Zhihai Chen,Hongjie Yu,Xiuzhen Pan,Xiaojun Zhou,Huaru Wang,Bo Wu,Haili Wang,Huamei Zhao,Ying Lin,Jianhua Yue,Zhen-Qiang Wu,Xiao-Wei He,Feng Gao,Abdul Hamid Khan,Jian Wang,Guoping Zhao,Yu Wang,Xiaoning Wang,Zhu Chen,Zhu Chen,George F. Gao +26 more
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TLDR
Clinical and pathological characterization of the human patients revealed the hallmarks of typical STSS, which to date had only been associated with GAS infection, and multiple lines of evidence confirmed that highly virulent strains of SS2 were the causative agents of both outbreaks.Abstract:
Background Streptococcus suis serotype 2 (S. suis 2, SS2) is a major zoonotic pathogen that causes only sporadic cases of meningitis and sepsis in humans. Most if not all cases of Streptococcal toxic shock syndrome (STSS) that have been well-documented to date were associated with the nonSS2 group A streptococcus (GAS). However, a recent large-scale outbreak of SS2 in Sichuan Province, China, appeared to be caused by more invasive deep-tissue infection with STSS, characterized by acute high fever, vascular collapse, hypotension, shock, and multiple organ failure.read more
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Emergence of Fatal PRRSV Variants: Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark
Kegong Tian,Xiuling Yu,Tiezhu Zhao,Youjun Feng,Zhen Cao,Chuanbin Wang,Yan Hu,Xizhao Chen,Dongmei Hu,Xinsheng Tian,Di Liu,Shuo Zhang,Xiaoyu Deng,Yinqiao Ding,Lu-Lu Yang,Yunxia Zhang,Haixia Xiao,Qiao Mingming,Bin-Bin Wang,Li-Li Hou,Xiaoying Wang,Yang Xinyan,Liping Kang,Ming Sun,Ping Jin,Shujuan Wang,Shujuan Wang,Yoshihiro Kitamura,Jinghua Yan,George F. Gao +29 more
TL;DR: This is the first comprehensive report documenting the 2006 epidemic of atypical PRRS outbreak in China and identifying the 30 amino-acid deletion in NSP2, a novel determining factor for virulence which may be implicated in the high pathogenicity of PRRSV, and will stimulate further study by using the infectious cDNA clone technique.
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Streptococcus suis, an important pig pathogen and emerging zoonotic agent-an update on the worldwide distribution based on serotyping and sequence typing.
Guillaume Goyette-Desjardins,Jean-Philippe Auger,Jianguo Xu,Mariela Segura,Marcelo Gottschalk +4 more
TL;DR: This review presents the worldwide distribution of serotypes and sequence types (STs), as determined by multilocus sequence typing, for pigs and humans between 2002 and 2013 and if these differences can be associated with specific serotypes or STs.
Journal ArticleDOI
Streptococcus suis: an emerging zoonotic pathogen
TL;DR: This review provides background information on the biology and molecular characteristics of this Gram-positive bacterium, and describes the clinical signs, pathology, epidemiology, diagnosis, and treatment of human infection with S suis.
Journal ArticleDOI
Streptococcus suis: an emerging human pathogen.
Heiman F. L. Wertheim,Ho Dang Trung Nghia,Walter R. J. Taylor,Walter R. J. Taylor,Constance Schultsz,Constance Schultsz +5 more
TL;DR: An overview of the emergence and clinical manifestations of S. suis infection in humans has been provided, with most cases originating in Southeast Asia, where there is a high density of pigs.
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Streptococcus suis: a new emerging or an old neglected zoonotic pathogen?
TL;DR: The present knowledge on S. suis infection in humans is critically reviewed, the hypotheses that may explain the 2005 outbreak are discussed and the repercussion of such an episode on the scientific community is discussed.
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