Journal ArticleDOI
Stress-induced immune dysfunction: implications for health.
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TLDR
PNI researchers have used animal and human models to learn how the immune system communicates bidirectionally with the central nervous and endocrine systems and how these interactions impact on health.Abstract:
Folk wisdom has long suggested that stressful events take a toll on health. The field of psychoneuroimmunology (PNI) is now providing key mechanistic evidence about the ways in which stressors--and the negative emotions that they generate--can be translated into physiological changes. PNI researchers have used animal and human models to learn how the immune system communicates bidirectionally with the central nervous and endocrine systems and how these interactions impact on health.read more
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Factors Affecting Wound Healing
Shujuan Guo,Luisa A. DiPietro +1 more
TL;DR: The factors discussed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, alcoholism, smoking, and nutrition, which may lead to therapeutics that improve wound healing and resolve impaired wounds.
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Psychological Stress in Childhood and Susceptibility to the Chronic Diseases of Aging: Moving toward a Model of Behavioral and Biological Mechanisms.
TL;DR: A biological embedding model is presented that maintains that childhood stress gets "programmed" into macrophages through epigenetic markings, posttranslational modifications, and tissue remodeling, and proposes that over the life course, these proinflammatory tendencies are exacerbated by behavioral proclivities and hormonal dysregulation, themselves the products of exposure to early stress.
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From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression
TL;DR: A biologically plausible, multilevel theory is proposed that describes neural, physiologic, molecular, and genomic mechanisms that link experiences of social-environmental stress with internal biological processes that drive depression pathogenesis and may shed light on several important questions including how depression develops, why it frequently recurs, and why it is strongly predicted by early life stress.
Journal ArticleDOI
Childhood maltreatment predicts adult inflammation in a life-course study
TL;DR: Childhood maltreatment is a previously undescribed, independent, and preventable risk factor for inflammation in adulthood, and may be an important developmental mediator linking adverse experiences in early life to poor adult health.
Journal ArticleDOI
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Premal H. Thaker,Liz Y. Han,Aparna A. Kamat,Jesusa M.G. Arevalo,Rie Takahashi,Chunhua Lu,Nicholas B. Jennings,Guillermo N. Armaiz-Pena,James A. Bankson,Murali Ravoori,William M. Merritt,Yvonne G. Lin,Lingegowda S. Mangala,Tae Jin Kim,Robert L. Coleman,Charles N. Landen,Yang Li,Edward Felix,Angela Sanguino,Robert A. Newman,Mary Lloyd,David M. Gershenson,Vikas Kundra,Gabriel Lopez-Berestein,Susan K. Lutgendorf,Steven W. Cole,Anil K. Sood +26 more
TL;DR: Chronic behavioral stress results in higher levels of tissue catecholamines, greater tumor burden and more invasive growth of ovarian carcinoma cells in an orthotopic mouse model, and β-adrenergic activation of the cAMP–PKA signaling pathway is identified as a major mechanism by which behavioral stress can enhance tumor angiogenesis in vivo and thereby promote malignant cell growth.
References
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Journal ArticleDOI
Caregiving as a risk factor for mortality: the Caregiver Health Effects Study.
Richard Schulz,Scott R. Beach +1 more
TL;DR: This study suggests that being a caregiver who is experiencing mental or emotional strain is an independent risk factor for mortality among elderly spousal caregivers.
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Regulation of Wound Healing by Growth Factors and Cytokines
Sabine Werner,Richard Grose +1 more
TL;DR: This review summarizes the results of expression studies that have been performed in rodents, pigs, and humans to localize growth factors and their receptors in skin wounds and reports on genetic studies addressing the functions of endogenous growth factors in the wound repair process.
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Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry
TL;DR: The present report meta-analyzes more than 300 empirical articles describing a relationship between psychological stress and parameters of the immune system in human participants to find that physical vulnerability as a function of age or disease also increased vulnerability to immune change during stressors.
Journal ArticleDOI
Accelerated telomere shortening in response to life stress
Elissa S. Epel,Elizabeth H. Blackburn,Jue Lin,Firdaus S. Dhabhar,Nancy E. Adler,Jason D. Morrow,Richard M. Cawthon +6 more
TL;DR: Evidence is provided that psychological stress--both perceived stress and chronicity of stress--is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, in peripheral blood mononuclear cells from healthy premenopausal women.
Journal ArticleDOI
Psychological Stress and Susceptibility to the Common Cold
TL;DR: Psychological stress was associated in a dose-response manner with an increased risk of acute infectious respiratory illness, and this risk was attributable to increased rates of infection rather than to an increased frequency of symptoms after infection.