Journal ArticleDOI
Structural changes in xanthan gum solutions during steam sterilization for sterile preparations.
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Steam sterilization of xanthan gum solutions at 121°C caused a decrease in the helix conformation as well as the molecular weight distribution with a corresponding increase in the coil structure, suggesting a two-step mechanism of disentanglement followed by degradation with the first step being predominant at higher concentrations.Abstract:
Steam sterilization of xanthan gum solutions at 121 degrees C caused a decrease in the helix conformation as well as the molecular weight distribution with a corresponding increase in the coil structure. The effect was directly related to the exposure time and inversely to the xanthan gum concentration, thus suggesting a two-step mechanism of disentanglement followed by degradation with the first step being predominant at higher concentrations. Mark-Houwink exponent of 0.9002 for the intrinsic viscosity of xanthan gum compared favorably with reported values in the literature. The model for intrinsic viscosity of a free draining coil yielded an expansion coefficient of 1.2 (independent of molecular weight) and a root mean square radius of unperturbed chain in the range of 189.5-368 nm. The root mean square unperturbed chain length increased with molecular weight without reaching an asymptotic value, thus indicating that the xanthan molecule behaved as a stiff chain.read more
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Xanthan hydrogel films: molecular conformation, charge density and protein carriers.
TL;DR: The preservation of LyZ native conformation after hydrogel loading explained the substantial bactericidal activity of LYZ loaded hydrogels and enables their use as active wound dressings.
Journal ArticleDOI
Comparative heterogeneity, molecular weights and viscosities of xanthans of different pyruvate and acetate content
TL;DR: In this article, four different xanthans derived from Xanthomanas campestris were characterized in dilute aqueous buffered solution (pH 7.0, ionic strength 0.3 M) using sedimentation velocity and sedimentation equilibrium in the analytical ultracentrifuge, supplemented by dynamic light scattering.
Journal ArticleDOI
Sterilization of Exopolysaccharides Produced by Deep-Sea Bacteria: Impact on Their Stability and Degradation
Emilie Rederstorff,Ahmed Fatimi,Corinne Sinquin,Jacqueline Ratiskol,Christophe Merceron,Claire Vinatier,Pierre Weiss,Sylvia Colliec-Jouault +7 more
TL;DR: Chemical sterilization using low-temperature ethylene oxide and a mixture of ionized gases (plasmas) was compared to the sterilization methods using gamma and beta radiations, and changes to both the physical and chemical properties of the sterilized exopolysaccharides were analyzed.
Journal ArticleDOI
Effect of Thermal Sterilization on the Selected Quality Attributes of Sweet and Sour Carp
TL;DR: In this article, a ready-to-eat sweet and sour carp was developed and the effects of sterilization temperature (110, 115, 121, and 130°C) on the selected properties, including heat penetration characteristics, as well as rheological, instrumental color, texture, and sensory attributes, were investigated at the same lethality value (F0) of 4.5 min.
Journal ArticleDOI
Formulation, Evaluation, and Clinical Assessment of Novel Solid Lipid Microparticles of Tetracycline Hydrochloride for the Treatment of Periodontitis
TL;DR: In this paper, a solvent-free process to formulate long-acting microparticles of tetracycline hydrochloride (TH) using hot melt extrusion granulation process coupled with size reduction using comil for the treatment of periodontitis was investigated using hydrogenated castor oil (HCO) as hydrophobic matrix former.
References
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Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Book
Principles of colloid and surface chemistry
Paul C. Hiemenz,Raj Rajagopalan +1 more
TL;DR: Colloid and surface chemistry - scope and variables sedimentation and diffusion and their equilibrium solution thermodynamics - osmotic and Donnan equilibria the rheology of dispersions static and dynamic light scattering and other radiation scattering surface tension and contact angle - application to pure substances adsorption from solution and monolayer formation colloidal structures in surfactant solutions - association colloids adsorction at gas-solid interfaces van der Waals forces the electrical double layer and double-layer interactions electrophoresis and other electrokinetic phenomena electrostatic and polymer-induced
Biophysical chemistry. Part III, The behavior of biologicalmacromolecules
Charles R. Cantor,Paul Schimmel +1 more
TL;DR: That system is specific in publications sharing across various users and nations, and e-book Biophysical Chemistry Part Iii The Behavior Of Biological Macromolecules Their Biophysical chemistry Pt 3 Download PDF can be also downloaded from here.
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Conformational investigation on the bacterial polysaccharide xanthan.
Michel Milas,Marguerite Rinaudo +1 more
TL;DR: The conformation of xanthan has been investigated as a function of temperature, ionic strength, and polymer concentration; a reversible transition induced by temperature is demonstrated; the melting temperature is directly correlated to the total ionic-strength and is independent of the polymer concentration.