Journal ArticleDOI
Structure Revision of Mitragynaline, an Indole Alkaloid in Mitragyna speciosa.
Hiromitsu Takayama,Hayato Ishikawa,Mika Kurihara,Mariko Kitajima,Shin-ichiro Sakai,Norio Aimi,Hiroko Seki,Kentaro Yamaguchi,Ikram M. Said,Peter J. Houghton +9 more
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TLDR
The structure of mitragynaline, an indole alkaloid isolated from Malaysian Mitragyna speciosa, was revised as formula 3 by analysis of the NMR spectra measured at low temperature and by chemical transformation with DDQ oxidation from the known alkaloids as mentioned in this paper.Abstract:
The structure of mitragynaline, an indole alkaloid isolated from Malaysian Mitragyna speciosa, was revised as formula 3 by analysis of the NMR spectra measured at low temperature and by chemical transformation with DDQ oxidation from the known alkaloid mitragynine ( 5 ).read more
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Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.
Hiromitsu Takayama,Hayato Ishikawa,Mika Kurihara,Mariko Kitajima,Norio Aimi,Dhavadee Ponglux,Fumi Koyama,Kenjiro Matsumoto,Tomoyuki Moriyama,Leonard T. Yamamoto,Kazuo Watanabe,Toshihiko Murayama,Syunji Horie +12 more
TL;DR: The oxidative derivatives of mitragynine were found as opioid agonists with higher potency than morphine in the experiment with guinea pig ileum, and 2 induced an analgesic activity in the tail flick test in mice.
Journal ArticleDOI
Chemical characterization and in vitro cyto- and genotoxicity of ‘legal high’ products containing Kratom (Mitragyna speciosa)
Ana Sofia Oliveira,Sónia Fraga,Félix Carvalho,Ana Margarida Araújo,Cristiana Pereira,Cristiana Pereira,João Paulo Teixeira,João Paulo Teixeira,Maria de Lourdes Bastos,Paula Guedes de Pinho +9 more
TL;DR: The obtained results revealed an inconsistency between the information (‘power’) provided in labels and the MG content, which suggests that other substances present in the extracts or interactions involving Kratom components might be responsible for the observed effects.
Dissertation
Volatile compounds and alkaloids from the aqueous extract of mitragyna speciosa and their in vitro and in vivo anti-inflammatory studies / Norsita Tohar
TL;DR: In this article, aqueous extract of the leaves of M. speciosa, MSEA was further investigated for its in vivo (anti-ulcer test) anti-inflammatory activity.
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Journal ArticleDOI
Structure revision of mitragynaline, an indole alkaloid in Mitragyna speciosa
Hiromitsu Takayama,Hayato Ishikawa,Mika Kurihara,Mariko Kitajima,Shin-ichiro Sakai,Norio Aimi,Hiroko Seki,Kentaro Yamaguchi,Ikram M. Said,Peter J. Houghton +9 more
TL;DR: The structure of mitragynaline, an indole alkaloid isolated from Malaysian Mitragyna speciosa, was revised as formula 3 by analysis of the NMR spectra measured at low temperature and by chemical transformation with DDQ oxidation from the known alkaloids.