Studies on the Biological Properties of Polyene Antibiotics EVIDENCE FOR THE DIRECT INTERACTION OF FILIPIN WITH CHOLESTEROL
TLDR
The results suggest that filipin can interact stoichiometrically with cholesterol and that in membrane systems this interaction is capable of altering some of the physical properties of the membrane, thus providing a basis for Filipin-induced changes in membrane permeability.About:
This article is published in Journal of Biological Chemistry.The article was published on 1972-03-25 and is currently open access. It has received 283 citations till now. The article focuses on the topics: Filipin & Membrane permeability.read more
Citations
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CNS synaptogenesis promoted by glia-derived cholesterol
Daniela H. Mauch,Karl Nägler,Stefan Schumacher,Christian Göritz,Eva-Christina Müller,Albrecht Otto,Frank W. Pfrieger +6 more
TL;DR: Cholesterol complexed to apolipoprotein E-containing lipoproteins may explain the delayed onset of CNS synaptogenesis after glia differentiation and neurobehavioral manifestations of defects in cholesterol or lipoprotein homeostasis.
Journal ArticleDOI
Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance
TL;DR: The mode of action of antifungals and their mechanisms of resistance are discussed, and an attempt is made to discuss the correlation between fungal and bacterial resistance.
Journal ArticleDOI
Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. III. Molecular structure of the polyene antibiotic-cholesterol complexes
B. de Kruijff,Rudy A. Demel +1 more
TL;DR: Mechanisms of the polyene antibiotic induced permeability changes in membranes are proposed based on the analysis of the complexes of cholesterol, amphotericin B, nystatin, etruscomycin and pimaricin, which can be built with space-filling models.
Journal ArticleDOI
Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis
Montserrat Marí,Francisco Caballero,Anna Colell,Albert Morales,Juan Caballería,Anna Fernández,Carlos Enrich,José C. Fernández-Checa,Carmen García-Ruiz +8 more
TL;DR: A critical role is proposed for mitochondrial FC loading in precipitating SH, by sensitizing hepatocytes to TNF and Fas through mGSH depletion.
Journal ArticleDOI
Intracellular cholesterol transport
Laura Liscum,Natalie J. Munn +1 more
TL;DR: Liscum et al. as mentioned in this paper reviewed the current knowledge of cholesterol transport mecha- nisms and pathways and have described approaches that may help define cholesterol trafficking mechanisms in molecular de- tail.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction
TL;DR: The cholesterol controls the fluidity of the hydrocarbon chains of the phospholipid by disruption of the crystalline chain lattice of the gel phase, and by inhibiting the flexing of chains in the dispersed liquid crystalline phase.
Related Papers (5)
Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. III. Molecular structure of the polyene antibiotic-cholesterol complexes
B. de Kruijff,Rudy A. Demel +1 more