Open AccessJournal Article
Studies on the mechanism of skin tumor promotion.
Henry Hennings,R. K. Boutwell +1 more
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At a level which was effective as a skin tumor promoter, croton oil increased the rate of incorporation of tritiated precursors into mouse skin macromolecules and stimulation of RNA synthesis may be important in the process of promotion.Abstract:
At a level which was effective as a skin tumor promoter, croton oil increased the rate of incorporation of tritiated precursors into mouse skin macromolecules. After a single application of croton oil, the early 2- to 3-fold stimulation of RNA and protein synthesis and the 60% inhibition of DNA synthesis was followed by a 3-fold stimulation of DNA synthesis at 18 hr. The rates of macromolecular synthesis returned to normal levels within 7 days. A single application of cantharidin, a weak tumor promoter, stimulated both DNA and RNA synthesis in mouse skin. Treatment with either croton oil or cantharidin stimulated the synthesis of rapidly labeled RNA when measured 2 hr after treatment; stimulation of RNA synthesis may be important in the process of promotion. When an incision was made in initiated skin, tumors developed along the line of wound healing. Because croton oil, cantharidin, and other promoters cause hyperplasia and because wound healing causes a local stimulation of mitosis, a stimulation of cell division may be involved in promotion. A possible molecular mechanism of skin carcinogenesis is discussed.read more
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Multistage carcinogenesis in mouse skin
TL;DR: The mouse skin model of multistage carcinogenesis has for many years provided a conceptual framework for studying carcinogenesis mechanisms and potential means for inhibiting specific stages of carcinogenesis, and a summary of known inhibitors of specific stages and their proposed mechanisms of action is reviewed.
Book ChapterDOI
The sequential analysis of cancer development.
Emmanuel Farber,Ross Cameron +1 more
TL;DR: This chapter reviews the sequence of cellular and other changes during cancer development in selected sites in experimental animals and in humans and highlights the similarities and differences among the carcinogenic processes.
Journal ArticleDOI
In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1.
TL;DR: (1980).
References
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The disappearance of thymine dimers from dna: an error-correcting mechanism
TL;DR: The onset of DNA synthesis is associated with thymine dimer removal, which is suggested to be one step in cell recovery in resistant strains of E. coli.
Journal ArticleDOI
Evidence for the binding of polynuclear aromatic hydrocarbons to the nucleic acids of mouse skin: relation between carcinogenic power of hydrocarbons and their binding to deoxyribonucleic acid.
Peter Brookes,P. D. Lawley +1 more
TL;DR: Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of hydrocarbons and their Binding to Deoxyribonucleic Acid is presented.
Journal ArticleDOI
A new, quantitative, approach to the study of the stages of chemical cartinogenesis in the mouse's skin.
I Berenblum,P Shubik +1 more
TL;DR: A New, Quantitative, Approach to the Study of the Stages of Chemical Carcinogenesis in the Mouse's Skin and its Applications is presented.
Journal ArticleDOI
Repressed and active chromatin isolated from interphase lymphocytes.
Journal Article
A speculative review; the probable nature of promoting action and its significance in the understanding of the mechanism of carcinogenesis.
TL;DR: The nature of initiating action represents a specific, sudden, irreversible change in a normal cell, and whether this is brought about by a true somatic mutation, or whether it is only a mutation-like proc ess, is immaterial for the present discussion.