Journal ArticleDOI
Sustained release from lipid-core nanocapsules by varying the core viscosity and the particle surface area.
Eliézer Jäger,Cristina G. Venturini,Fernanda Poletto,Letícia Marques Colomé,João P. U. Pohlmann,Andressa Bernardi,Ana Maria Oliveira Battastini,Silvia Stanisçuaski Guterres,Adriana Raffin Pohlmann +8 more
TLDR
In conclusion, varying the CCT and SM concentrations the IndOEt release was controlled by the nanocapsule surface area and by the viscosity of the core, respectively.Abstract:
Based on the structure of polymeric nanocapsules containing a lipid-dispersed core composed of caprylic/capric trygliceride (CCT) and sorbitan monostearate (SM), we hypothesized that varying the core component concentrations the drug release kinetic could be modulated. Our objective was also to determine the parameters which were responsible for controlling the drug release kinetics. The nanocapsules were prepared by interfacial deposition of poly(epsilon-caprolactone). Interfacial hydrolysis of indomethacin ester (IndOEt) was used to simulate a sink condition of release. Mathematical modeling showed that the IndOEt half-lives increased (198 to 378 and 263 to 508 min) with the increase in the core lipid concentrations, and that the release mechanism was the anomalous transport. By increasing the SM concentration, the diameters were constant (around 250 nm) and the surface areas increased (from 1.06 x 10(4) to 1.51 x 10(4) cm2 x ml(-1)), while by increasing the CCT concentration, the diameters increased (215 to 391 nm) and the surface areas reduced (1.46 x 10(4) to 1.06 x 10(4) cm2 x ml(-1)). The presence of SM increased the viscosity of CCT and the IndOEt apparent permeability decreased from 4.26 x 10(-7) to 2.54 x 10(-7) cm x s(-1), while for CCT series, the apparent permeability was constant around 3.0 x 10(-7) cm x s(-1). A mathematical correlation was established and the IndOEt apparent permeability can be estimated by the SM concentration. In conclusion, varying the CCT and SM concentrations the IndOEt release was controlled by the nanocapsule surface area and by the viscosity of the core, respectively.read more
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Journal ArticleDOI
Poly(ϵ-caprolactone) microcapsules and nanocapsules in drug delivery
Adriana Raffin Pohlmann,Francisco N. Fonseca,Karina Paese,Cassia Britto Detoni,Karine Coradini,Ruy Cr Beck,Silvia Stanisçuaski Guterres +6 more
TL;DR: Poly(ϵ-caprolactone) (PCL), a biodegradable and biocompatible polymer, is useful to encapsulate a wide range of drugs making it an interesting material for the preparation of carriers with potential applications in therapeutics.
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Co-encapsulation of resveratrol and curcumin in lipid-core nanocapsules improves their in vitro antioxidant effects
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Journal ArticleDOI
Formulation of lipid core nanocapsules
Cristina G. Venturini,Eliézer Jäger,Catiuscia P. de Oliveira,Andressa Bernardi,Ana Maria Oliveira Battastini,Silvia Stanisçuaski Guterres,Adriana Raffin Pohlmann +6 more
TL;DR: In this paper, a supramolecular model for a new kind of nanocapsule prepared with triacylglycerol, sorbitan monostearate (SM), polyester and polysorbate 80.
Journal ArticleDOI
Free and nanoencapsulated curcumin suppress β-amyloid-induced cognitive impairments in rats: Involvement of BDNF and Akt/GSK-3β signaling pathway
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TL;DR: The findings demonstrate that administration of curcumin was effective in preventing behavioral impairments, neuroinflammation, tau hyperphosphorylation as well as cell signaling disturbances triggered by Aβ in vivo, and suggest thatCur-LNC in a dose 20-fold lower presented similar neuroprotective results compared to the effective dose of free curcuming.
Journal ArticleDOI
Neuroprotective Effects of Resveratrol Against Aβ Administration in Rats are Improved by Lipid-Core Nanocapsules
Rudimar Luiz Frozza,Andressa Bernardi,Juliana Bender Hoppe,André Meneghetti,Aline Matté,Ana Maria Oliveira Battastini,Adriana Raffin Pohlmann,Silvia Stanisçuaski Guterres,Christianne Gazzana Salbego +8 more
TL;DR: The results clearly show that by using lipid-core nanocapsules, resveratrol was able to rescue the deleterious effects of Aβ1-42 while treatment with RSV presented only partial beneficial effects.