Journal ArticleDOI
Sympathetic Nerve Stimulation Versus Pancreatic Norepinephrine Infusion in the Dog: 1) Effects on Basal Release of Insulin and Glucagon
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TLDR
Whether pancreatic norepinephrine infusions could reproduce the inhibition of insulin secretion and the stimulation of glucagon secretion observed during sympathetic nerve stimulation in halothane-anesthetized dogs was investigated.Abstract:
We investigated whether pancreatic norepinephrine (NE) infusions could reproduce the inhibition of insulin secretion and the stimulation of glucagon secretion observed during sympathetic nerve stimulation in halothane-anesthetized dogs. Three minutes of stimulating the sympathetic nerves (8 Hz, 1 msec, 10 mA, n = 6) surrounding the pancreatic artery decreased both the blood flow in the superior pancreatic vein (SPV) (Δ = -1.7 ± 0.6 ml/min, P < 0.05) and the basal pancreatic output of immunoreactive insulin (IRI) (Δ = –79 ± 5%, P < 0.001). SPV levels of NE increased by 683 ± 177 pg/ml (P < 0.02). Infusion of NE into the superior pancreatic artery at the low dose of 12 ng/min (n = 6) reproduced this increase of SPV levels of NE (Δ= +740 ± 130 pg/ml; P < 0.01) and caused a small reduction of SPV blood flow (Δ= -1.0 ± 0.4 ml/min, P < 0.05), but did not change pancreatic IRI (Δ= -26 ± 16%, NS). The medium dose of NE (120 ng/min, n = 6) reproduced the nerve stimulation-induced decrease of SPV blood flow (Δ= -1....read more
Citations
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Journal ArticleDOI
Insulin and glucagon secretion in swimming mice: effects of autonomic receptor antagonism.
Sven Karlsson,Bo Ahrén +1 more
TL;DR: To study the regulation of islet hormone secretion in exercise-stress, a swimming mouse model was developed and the ganglionic antagonist hexamethonium prevented the swimming-induced inhibition of glucose-stimulated insulin secretion, indicating involvement of nerves in the inhibition.
Journal ArticleDOI
Glucagon secretory response to hypoglycaemia, adrenaline and carbachol in streptozotocin-diabetic rats.
TL;DR: It is concluded that carbachol-stimulated glucagon secretion is impared concomitantly with the impared glucagon response to hypoglycaemia in streptozotocin-diabetic rats, whereas adrenaline-induced glucagon gland secretion is exaggerated.
Patent
Brown adipose tissue utilization through neuromodulation
Abhi Vase,Johann Neisz +1 more
TL;DR: In this article, the authors used temperature increases in Brown adipose tissue (BAT) during intraoperative test stimulations to determine the proper nerve electrode placement for implantation for improved neurostimulation to treat obesity.
Journal ArticleDOI
Liver releases galanin during sympathetic nerve stimulation.
TL;DR: It is concluded that, despite the known significant galanin content of the gut, little Galanin is released from this organ during sympathetic activation, in contrast, the liver contains and releases significant amounts of the peptide during sympatheticactivation.
Journal ArticleDOI
Stimulation of Nerves Innervating the Dog's Pancreas
TL;DR: The results of radioimmunological assay of blood samples showed that in the intact pancreas, stimulation of the vagus nerve caused a considerable increase in insulin secretion, no significant change in glucagon secretion, and a decrease in C-peptide secretion.
References
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Journal ArticleDOI
Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats
Carl R Morgan,Arnold Lazarow +1 more
TL;DR: A two antibody system of insulin assay for immunoassay of insulin induces the production of specific nonprecipitating antibodies, both in experimental animals and in humans.
Journal ArticleDOI
Pancreatic Neuroendocrinology: Peripheral Neural Mechanisms in the Regulation of the Islets of Langerhans*
TL;DR: The anatomy of the islet in relation to its vascular supply and both motor and sensory autonomic nerves, which may play a role in altering the secretion rate of islet hormones are described.
Journal ArticleDOI
Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion.
TL;DR: Augmentation des connaissances sur l'importance du controle nerveux des fonctions des ilots sous certaines conditions physiologiques.
Journal ArticleDOI
Inhibition of Insulin Release by Norepinephrine in Man
Daniel Porte,Robert H. Williams +1 more
TL;DR: Normal subjects were given glucose or tolbutamide alone and during intravenous infusions of norepi-nephrine, and it was concluded that norepinephrine inhibits the release of insulin from pancreatic beta cells.
Journal ArticleDOI
Nerve fibers in the gut and pancreas of the rat displaying neuropeptide-Y immunoreactivity. Intrinsic and extrinsic origin.
TL;DR: In this article, immunoreactive neuropeptide Y (NPY) was demonstrated in neuronal elements in the gut and pancreas of the rat and was demonstrated to play a role in the regulation of intramural neuronal activities, smooth muscle tone, and local blood flow.