Journal ArticleDOI
Sympathetic Nerve Stimulation Versus Pancreatic Norepinephrine Infusion in the Dog: 1) Effects on Basal Release of Insulin and Glucagon
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TLDR
Whether pancreatic norepinephrine infusions could reproduce the inhibition of insulin secretion and the stimulation of glucagon secretion observed during sympathetic nerve stimulation in halothane-anesthetized dogs was investigated.Abstract:
We investigated whether pancreatic norepinephrine (NE) infusions could reproduce the inhibition of insulin secretion and the stimulation of glucagon secretion observed during sympathetic nerve stimulation in halothane-anesthetized dogs. Three minutes of stimulating the sympathetic nerves (8 Hz, 1 msec, 10 mA, n = 6) surrounding the pancreatic artery decreased both the blood flow in the superior pancreatic vein (SPV) (Δ = -1.7 ± 0.6 ml/min, P < 0.05) and the basal pancreatic output of immunoreactive insulin (IRI) (Δ = –79 ± 5%, P < 0.001). SPV levels of NE increased by 683 ± 177 pg/ml (P < 0.02). Infusion of NE into the superior pancreatic artery at the low dose of 12 ng/min (n = 6) reproduced this increase of SPV levels of NE (Δ= +740 ± 130 pg/ml; P < 0.01) and caused a small reduction of SPV blood flow (Δ= -1.0 ± 0.4 ml/min, P < 0.05), but did not change pancreatic IRI (Δ= -26 ± 16%, NS). The medium dose of NE (120 ng/min, n = 6) reproduced the nerve stimulation-induced decrease of SPV blood flow (Δ= -1....read more
Citations
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NGN3 Expression in Definitive Endoderm Progenitors Specifies Pancreatic Endocrine Precursors
TL;DR: NGN3 expression in DEPs specifies pancreatic endocrine fate and its role in cell reprograming is described.
Dissertation
Electrophysiological characterization of insulin secreting beta-cells in pancreatic tissue slices
TL;DR: The study showed pancreatic tissue slices as a promising, less invasive method to study the function of β-cells and will serve as a suitable system to gain further insight into the complex interactions controlling blood glucose homeostasis.
References
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Journal ArticleDOI
Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats
Carl R Morgan,Arnold Lazarow +1 more
TL;DR: A two antibody system of insulin assay for immunoassay of insulin induces the production of specific nonprecipitating antibodies, both in experimental animals and in humans.
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Pancreatic Neuroendocrinology: Peripheral Neural Mechanisms in the Regulation of the Islets of Langerhans*
TL;DR: The anatomy of the islet in relation to its vascular supply and both motor and sensory autonomic nerves, which may play a role in altering the secretion rate of islet hormones are described.
Journal ArticleDOI
Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion.
TL;DR: Augmentation des connaissances sur l'importance du controle nerveux des fonctions des ilots sous certaines conditions physiologiques.
Journal ArticleDOI
Inhibition of Insulin Release by Norepinephrine in Man
Daniel Porte,Robert H. Williams +1 more
TL;DR: Normal subjects were given glucose or tolbutamide alone and during intravenous infusions of norepi-nephrine, and it was concluded that norepinephrine inhibits the release of insulin from pancreatic beta cells.
Journal ArticleDOI
Nerve fibers in the gut and pancreas of the rat displaying neuropeptide-Y immunoreactivity. Intrinsic and extrinsic origin.
TL;DR: In this article, immunoreactive neuropeptide Y (NPY) was demonstrated in neuronal elements in the gut and pancreas of the rat and was demonstrated to play a role in the regulation of intramural neuronal activities, smooth muscle tone, and local blood flow.