Journal ArticleDOI
Synergistic effect of angiotensin-(1-7) on bradykinin arteriolar dilation in vivo.
Maria Aparecida Oliveira,Zuleica Bruno Fortes,Robson A.S. Santos,Malesh C Kosla,Maria Helena Catelli de Carvalho +4 more
TLDR
The potentiation of BK-induced vasodilation by Ang-(1-7) is a receptor-mediated phenomenon dependent on cyclooxygenase-related products and NO release.About:
This article is published in Peptides.The article was published on 1999-10-01. It has received 113 citations till now. The article focuses on the topics: Angiotensin II & Vasodilation.read more
Citations
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Journal ArticleDOI
Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system
TL;DR: Recent findings related to the biological role of the ACE2/Ang-(1-7)/Mas arm in the cardiovascular and renal systems, as well as in metabolism are discussed.
Journal ArticleDOI
Angiotensin-(1-7): an update.
TL;DR: The evidence that Ang-(1-7) takes an important part of the mechanisms aimed to counteract the vasoconstrictor and proliferative effects of Ang II is summarized.
Journal ArticleDOI
Potential influence of COVID-19/ACE2 on the female reproductive system.
TL;DR: The available evidence suggests that ACE2 is widely expressed in the ovary, uterus, vagina and placenta, and it is believed that apart from droplets and contact transmission, the possibility of mother-to-child and sexual transmission also exists.
Journal ArticleDOI
Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator.
TL;DR: PKA did not correct the coagulant defect in factor XI deficient plasma, was purified from HUVEC cultured in factor XII-deficient serum, was not detected by antibody to factor XII, did not activate FXI, and was not inhibited by a neutralizing antibody to FXII.
Journal ArticleDOI
Angiotensin-(1-7): Cardioprotective Effect in Myocardial Ischemia/Reperfusion
TL;DR: The results suggest that the antiarrhythmogenic effect of low concentrations of Ang-(1-7) is mediated by a specific receptor and that release of endogenous prostaglandins contributes to the alleviation of reversible and/or irreversible ischemia-reperfusion injury.
References
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Journal ArticleDOI
Angiotensin-(1-7) Dilates Canine Coronary Arteries Through Kinins and Nitric Oxide
TL;DR: The results suggest that increases in circulating levels of Ang-(1-7) accompanying long-term administration of converting enzyme inhibitors or Ang II receptor blockers may contribute to the cardioprotective actions of these drugs.
Journal ArticleDOI
Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors.
Robson A.S. Santos,Maria José Campagnole-Santos,Nilo César do Vale Baracho,Marco Antônio Peliky Fontes,Luciana Costa Silva,Liomar A.A. Neves,Djenane Ramalho de Oliveira,Sordaine M. Caligiorne,André Ricardo Vale Rodrigues,Carlos Gropen,Wania da Silva Carvalho,Ana Cristina Simões e Silva,Mahesh C. Khosla +12 more
TL;DR: Results show that A-779 is a potent and selective antagonist for Ang-(1-7), and data indicate that specific angiotensin receptors mediate the central and peripheral actions of Ang-( 1-7).
Journal ArticleDOI
Metabolism of Angiotensin-(1–7) by Angiotensin-Converting Enzyme
TL;DR: It is suggested that increased levels of Ang-(1-7) following ACE inhibition may be due, in part, to decreased metabolism of the peptide.
Journal ArticleDOI
N-Domain–Specific Substrate and C-Domain Inhibitors of Angiotensin-Converting Enzyme: Angiotensin-(1–7) and Keto-ACE
Peter A. Deddish,Branislav M. Marcic,Herbert L. Jackman,Huan Zhu Wang,Randal A. Skidgel,Ervin G. Erdös +5 more
TL;DR: Keto-ACE inhibited bradykinin and Ang I hydrolysis by C-ACE in approximately a 38- to 47-times lower concentration than by N-ACE; this potentiation of kinins at the receptor level can explain some of the well-documented kininlike actions of Ang-(1-7).
Journal ArticleDOI
Angiotensin-(1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide
TL;DR: This study evaluated whether the potentiation of the BK-induced vasodilation by Ang-(1-7) may be attributable to inhibition of BK metabolism, release of nitric oxide, or both, and how this affects canine coronary artery rings.
Related Papers (5)
Angiotensin-(1-7) Dilates Canine Coronary Arteries Through Kinins and Nitric Oxide
Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
Robson A.S. Santos,Ana Cristina Simões e Silva,Christine Maric,Denise M. R. Silva,Raquel Pillar Machado,Insa de Buhr,Silvia Heringer-Walther,Sérgio Veloso Brant Pinheiro,Myriam Teresa Lopes,Michael Bader,Elizabeth Pereira Mendes,Virgina Soares Lemos,Maria José Campagnole-Santos,Heinz-Peter Schultheiss,Robert C. Speth,Thomas Walther +15 more