Journal ArticleDOI
Synthesis, Acidity Constants and Tautomeric Structure of 7-Arylhydrazono[1,2,4]Triazolo[3,4-b][1,3,4]thiadiazines in Ground and Excited States
Ahmad S. Shawali,Ibrahim F. Zeid,Mahmoud H. Abdel-Kader,Alsayed A. M. Elsherbini,Farag M. A. Altalbawy +4 more
TLDR
In this article, the acid dissociation constants pK and pK* in ground and excited states, respectively, were determined from the reactions of 4-amino-5-phenyl-4H-[1,2,4]triazole-3-thiol 2 and 2-(2-naphthyl)-2-oxoethanehydrazonoyl bromides 1 and the spectral data indicated that the title compounds exist predominantly in the hydrazone tautomeric form.Abstract:
7-Arylhydrazono[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines 4 were synthesized from the reactions of 4-amino-5-phenyl-4H-[1,2,4]triazole-3-thiol 2 and 2-(2-naphthyl)-2-oxoethanehydrazonoyl bromides 1 and their acid dissociation constants pK and pK*, in the ground and excited states, respectively, were determined. Both pK and pK* constants were correlated by Hammett equation. The pK and the spectral data presented indicate that the title compounds exist predominantly in the hydrazone tautomeric form.read more
Citations
More filters
Journal ArticleDOI
Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities
TL;DR: All newly synthesized compounds were screened for their antimicrobial activity and all the compounds screened showed good or moderate activity except compounds 2, 7a, 7b, 8 and 9b.
Journal ArticleDOI
Triazolothiadiazoles and triazolothiadiazines--biologically attractive scaffolds.
TL;DR: This review article is an effort to summarize medicinal chemistry investigations over the last decade, in search for new N-bridged heterocycles which can be a rich source of promising biological activities.
Journal ArticleDOI
Hydrazonoyl halides: Useful building blocks for the synthesis of arylazoheterocycles
Journal ArticleDOI
Synthesis of some new azo dyes derived from 4-hydroxy coumarin and spectrometric determination of their acidic dissociation constants
TL;DR: In this article, a series of azo coumarin dyes was synthesized by coupling of 4-hydroxymethylcoumarin and diazonium salts, which were characterized by IR, 1 HNMR and UV-Visible spectra.
Journal ArticleDOI
Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective Drugs
TL;DR: More light is shed on the synthesis of 1,2,4-triazoles and its application as a biologically active moiety and they might also be suitable as antiviral and anti-infective drugs.
References
More filters
Journal ArticleDOI
Studies on Coördination Compounds. I. A Method for Determining Thermodynamic Equilibrium Constants in Mixed Solvents1, 2
Journal ArticleDOI
Improved syntheses of 5‐substituted‐4‐amino‐3‐mercapto‐(4H)‐1,2,4‐triazoles
Jack R. Reid,Ned D. Heindel +1 more
Journal ArticleDOI
The structures of some 5-pyrazolones and derived 4-arylazo-5-pyrazolones
TL;DR: In this paper, infrared and N.M.R. spectroscopy were used to assign structures to 3,4,4-trimethyl-5-pyrazolone, 3, 4,4dimethyl-3-methyl-5 -p-acetoxyphenylazo-5 pyrazolones.