Showing papers in "Journal of Heterocyclic Chemistry in 1976"

TL;DR: In this article, the required hydroxyl derivatives of cis-3-aminocyclopentanemethanol with 3-ethoxyacryloyl isocyanate gave N-(3]-N′-[hydroxy]- or dihydroxy(hydroxy-methyl)cyclopentyl]ureas.

TL;DR: In this paper, the synthesis of covalently linked porphyrin dimers and trimers was described by transeslerifying 5,10,15,20,20-tetra(4-carbomethoxy-phenyl)porphyrin with ethylene glycol.

TL;DR: The o-diamine, 3,4diamino-1,2,5-thiadiazole (2), was synthesized from 3-4-dichloro-1.2, 5th-thiamine (3) hy three methods: Aqueous glyoxal cyclized 2 into pyrazine 2,2-dioxide (pyrazine) as mentioned in this paper.

TL;DR: A series of tricyclic pyrazoles were prepared from intermediates available from steroid total synthesis and tested for antiarrhythmic and antiinflammatory activity as mentioned in this paper, and the results showed that the pyrazole was effective in both cases.

TL;DR: Aroylphenylacetylenes (I) reacted with ethyl and phenyl hydrazinecarboxylates (II) to give ω-aroylacetophenone-N-ethoxy carbonyl-(Vla-f) and N-phenoxycarbonyl--(VIg-l) hydrazones, respectively.

TL;DR: In this paper, the position of the nmr signals for the enolic proton was investigated for elucidation of the tautomeric structures of tenuazonic acid, showing that the strength of their intramolecular hydrogen-bonding is weaker than those of acyclic β,β′-triketones and six-membered cyclic triketones.

TL;DR: In this article, the same reagents were used to give the blocked 4-amino-8-ribosyl- and 4-oxo-3H-8 ribosyl)-pyrazyl-pyrazolo[ 1,5a]-1,3,5-triazine (9 and 15), respectively.

TL;DR: In this article, the use of the free base of compounds corresponding to III do not cyclize directly but lead instead to the intermediate Schiff bases which are subsequently cyclized to the desired benzodiazepines by treatment with hydrochloric acid.

TL;DR: In this article, the rates of the mononuclear heterocyclic rearrangement of the phenylhydrazone of 3-benzoyl-5-phenyl-1,2,4-oxadiazole (1) into 2,5-diphenyl-4-Benzoylamino-1.2,3-triazole (II) have heen measured in dioxane/water (50:50, v:v) in the range of pS+ 3.8-12.2 at

TL;DR: In this paper, the pKa s of the furanboronic acids and their formyl, acetyl and methyl derivatives were determined in order to investigate the influence of electronic and steric effects on the acidity of the boronic group.

TL;DR: In this paper, the mechanisms of formation of 2-amino-4-phenyl-5-arylazothiazoles from phenylglyoxalyl bromide arylhydrazones (III) with thiourea in ethanol were investigated.

TL;DR: In this paper, a multi-step reaction sequence form 3,5-diamino-4H-1,2,6-thiadiazine 1,1-dioxide was used to obtain lead tetraacetate.

TL;DR: A detailed account of chemical, physico-chemical, spectroscopic and theoretical studies related to the phosphole aromaticity problem is given and the present conflicting position is discussed in this paper.

TL;DR: In this article, 1-Phenylthymine and the carbocyclic analog of thymidine were obtained in yields of 84-87% by cyclizing the appropriate 3-methoxy-2-methylacryloylureas in dilute sulfuric acid.

TL;DR: Partial mclhylalion of gallopropiophenonc (4) followed by benzylation and base-catalyzed condensation with ethyl acetate yielded 3-(2-benzyloxy-3,4-din]etlK>xy)benzoyl-2-butanonc (6).

TL;DR: In this paper, an explanation for observed differences in azido/tetrazole equilibrium between azole series and azine or thiazole series is suggested, based on the fact that the form of tetrazole is more dominant than azide.

TL;DR: The synthesis of 2-amino-7-(β-D-riholuranosyl)pyrrolo[2,3-d ]pyrimidin-4-one (7-deazaguanos-ine, a nucleoside Q and Q* analog, has been accomplished hy two independcnl routes.

TL;DR: Oxidation of 2-acetyl-2,3-dihydro-3-disubstituted indazoles 5a and 5c gave quinoid compounds 20a, 20b, 24a and 24b, which could be isomerized to 3H-indazoles upon removal of the acetyl group.

TL;DR: The enantiomers of a minor hallucinogen, S(+)- and R(-)-3-(2-aminopropyl)indole (α-methyltryptamine) (6a and 6b) were synthesized via a 5-step manipulation from D- and L-tryptophan ethyl ester hydrochloride, respectively as discussed by the authors.

TL;DR: The reaction of acids with phosphorus pentachloride resulted in the key intermediates, the ehloroearboxycthyl-3,4-dimethoxybenzenesulfonamides as discussed by the authors, the latter was cyelized to 4,5-dihydro-7,8-dirnelhoxybenzothizepine-3 -one 1, 1-dioxide.

TL;DR: Several electron attracting groups have been substituted on the nitrogen atom to decrease the electron density of the pyrrole ring in order to make it more suitable for photoaddition reactions as discussed by the authors.

TL;DR: In this paper, the synthesis of 2-amino-1,8-naphthyridine derivatives with trifluoromethyl is described along with their conversion to the corresponding 1,8 naphthyanidin-2(1H)ones.

TL;DR: In this paper, the reaction of arylsulfonyl, pyridylearbonyl and arylalkylhydrazines with 2,4-dinitrophenyl-pyridinium chloride was shown to obtain N-iminopyrideinium ylides.

TL;DR: In this paper, O-Dilithiooximes were condensed with aldehydes and ketones to give β-hydroxyoximes which were acid-cyclized to give the 2-isoxazoline.

TL;DR: In this article, the penlahydroxy flavone, quercetin, was observed to proceed in distinct stages from the reaction mixture (methyl sulfale/potassium carbonate/acetone), the isolation of three major intermediates, a mono-, a di- and a trimethyl ether and their identification as the naturally occurring ethers: tamarixelin, ombuin and ayanin is described.

TL;DR: In this article, the 2-amino-1,3,4-thiadiazole with 1,3-dicarbonyl compounds are described, and the structure of the latter compound is confirmed by a synthesis of the alternative isomeric structure.