Journal ArticleDOI
Synthesis of angiotensinogen by isolated rat liver cells and its regulation in comparison to serum albumin
K. Weigand,H. Wernze,C. Falge +2 more
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TLDR
After 5 hr incubation hydrocortisone had stimulated the incorporation of radioactive leucine into total protein, the albumin synthesis by 43%, and the angiotensinogen synthesis by 142%.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1977-03-07. It has received 40 citations till now. The article focuses on the topics: Serum albumin & Bovine serum albumin.read more
Citations
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Journal ArticleDOI
Cloning and sequence analysis of cDNA for rat angiotensinogen.
Hiroaki Ohkubo,Ryoichiro Kageyama,Mayumi Ujihara,Tadaaki Hirose,Seiichi Inayama,Shigetada Nakanishi +5 more
TL;DR: A mixture of tetradecamer oligodeoxyribonucleotides complementary to the codons specifying the carboxyl-terminal sequence, Ile-His-Pro-Phe-His, of angiotensin was chemically synthesized and used for the isolation of a cDNA clone specific for angiotENSinogen from a c DNA bank of rat liver mRNA sequences.
Journal ArticleDOI
Molecular biology of angiotensinogen.
Kevin R. Lynch,Michael J. Peach +1 more
TL;DR: A critical review of the literature on the biology of this protein, with an emphasis on recent molecular biological studies, indicates that angiotensinogen functions solely as an extracellular reservoir of angiotENSin peptides.
Journal ArticleDOI
Hormonal control of angiotensinogen production
TL;DR: It is concluded that hepatic angiotensinogen biosynthesis is under hormonal control, which may in part explain the pathogenesis of hypertension associated with certain disease states.
Journal ArticleDOI
Immunocytochemical localization of angiotensinogen in rat liver and kidney.
TL;DR: The localization of these granular formations under the brush border suggests that angiotensinogen is reabsorbed from the glomerular ultrafiltrate rather than synthesized in the kidney.
Journal ArticleDOI
Immunocytochemical localization of angiotensinogen in the rat brain.
Walter G. Thomas,Conrad Sernia +1 more
TL;DR: The widespread distribution of angiotens inogen-like immunoreactivity supports the view that it is synthesized in the central nervous system and forms part of a brain renin-angiotensin system.
References
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Journal ArticleDOI
Immunochemical quantitation of antigens by single radial immunodiffusion
TL;DR: By standardizing the technical conditions of the experiment it is possible to use this principle for the immunochemical determination of antigens, and the lower limit of the method was found to correspond to 0·0025 μg of antigen, and to an antigen concentrations of 1·25 μg per ml.
Journal ArticleDOI
HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS: A Biochemical and Fine Structural Study
M. N. Berry,Daniel S. Friend +1 more
TL;DR: Cytoplasmic vacuolization in a small percentage of cells and potassium loss are the only indications of cell injury detected, and the isolated cells are comparable to normal hepatic parenchymal cells in situ in appearance and function.
Journal ArticleDOI
CORRELATED MORPHOMETRIC AND BIOCHEMICAL STUDIES ON THE LIVER CELL I. Morphometric Model, Stereologic Methods, and Normal Morphometric Data for Rat Liver
TL;DR: Stereologic methods which allow efficient and reliable quantitative evaluation of sectioned liver tissue are presented and validity and applicability of the method are discussed, and the data are compared with available information from other studies.
Journal ArticleDOI
A convenient, rapid and sensitive method for measuring the incorporation of radioactive amino acids into protein
Rusty J. Mans,G.David Novelli +1 more
TL;DR: The assay technique combines features of the filter-paper assay, efficient washing and extraction procedure, and a filter- paper counting procedure to permit the handling of 50 to 100 samples simultaneously with the same counting efficiency as the conventional method.
Journal ArticleDOI
The renin-angiotensin system (first of two parts).
Suzanne Oparil,Edgar Haber +1 more
TL;DR: The role of the kidney in blood-pressure regulation was established by TIGERSTEDT and Bergman at the close of the 19th century as discussed by the authors, who produced hypertension in dogs by injecting a cr...
Related Papers (5)
Hormonal control of plasma renin substrate; (angiotensinogen).
Regulation of Net Biosynthesis of Serum Albumin and Acute Phase Plasma Proteins INDUCTION OF ENHANCED NET SYNTHESIS OF FIBRINOGEN, α1-ACID GLYCOPROTEIN, α2 (ACUTE PHASE)-GLOBULIN, AND HAPTOGLOBIN BY AMINO ACIDS AND HORMONES DURING PERFUSION OF THE ISOLATED NORMAL RAT LIVER
David W. John,Leon L. Miller +1 more