Journal ArticleDOI
Synthesis of monoacylated derivatives of 1,2- cyclohexanediamine. Evaluation of their catalytic activity in the preparation of Wieland-Miescher ketone.
Ángel L. Fuentes de Arriba,David G. Seisdedos,Luis Simón,Victoria Alcázar,César Raposo,Joaquín R. Morán +5 more
TLDR
Ureas, carbamoyl derivatives, amides, and sulfonamides can be easily prepared from the strained (R,R)-cylohexanediamine urea in high yield, leaving a free amino group that shows good catalytic activity in intramolecular aldol condensations.Abstract:
Ureas, carbamoyl derivatives, amides, and sulfonamides can be easily prepared from the strained (R,R)-cylohexanediamine urea (1) in high yield, leaving a free amino group that shows good catalytic activity in intramolecular aldol condensations. The preparation of Wieland−Miescher ketone has been studied with these catalysts.read more
Citations
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Asymmetric Organocatalytic Cyclization and Cycloaddition Reactions
Albert Moyano,Ramon Rios +1 more
Journal ArticleDOI
Catalytic Enantioselective Desymmetrization Reactions to All-Carbon Quaternary Stereocenters.
TL;DR: The advances in the construction of all-carbon quaternary stereocenters via catalytic enantioselective desymmetrization of prochiral and meso-compounds are summarized and synthetic opportunities still available are outlined.
Journal ArticleDOI
Efficient Copper(II)-Catalyzed Transamidation of Non-Activated Primary Carboxamides and Ureas with Amines
Min Zhang,Min Zhang,Sebastian Imm,Sebastian Bähn,Lorenz Neubert,Helfried Neumann,Matthias Beller +6 more
TL;DR: Amid(e) them all: primary carboxamides and ureas react with aromatic and aliphatic amines in the presence of a copper catalyst to give a wide range of functionalized amides.
Journal ArticleDOI
Synthesis and separation of cucurbit[n]urils and their derivatives
Hang Cong,Xing Long Ni,Xin Xiao,Ying Huang,Qian-Jiang Zhu,Sai-Feng Xue,Zhu Tao,Leonard F. Lindoy,Gang Wei +8 more
TL;DR: This review surveys synthetic procedures for obtaining cucurbit[n]urils and their substituted derivatives together with the separation and purification of these remarkable compounds.
Journal ArticleDOI
Photochemically induced radical alkynylation of C(sp3)–H bonds
TL;DR: The present reaction enables construction of various tri- and tetra-substituted carbons from heteroatom-subStituted methylenes, methines and alkanes in a highly chemoselective fashion, and would serve as a new synthetic strategy for rapid construction of complex structures.
References
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Anion and ion-pair receptor chemistry: highlights from 2000 and 2001
TL;DR: Gale et al. as mentioned in this paper presented a review of metal-containing anion receptors in which the metal can function as: (i) a coordination site for the anion, (ii) an agent withdrawing electron density from the receptor, (iii) an organisational element in the receptor; (iv) a sensor; and (v) a co-bound guest in ion-pair receptor.
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Highly Enantioselective Direct Conjugate Addition of Ketones to Nitroalkenes Promoted by A Chiral Primary Amine−Thiourea Catalyst
Hongbing Huang,Eric N. Jacobsen +1 more
TL;DR: Broad substrate scope is described, with nitroalkenes bearing either aromatic or aliphatic substituents and a wide variety of ketones shown to be useful reacting partners.
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A Chiral Primary Amine Thiourea Catalyst for the Highly Enantioselective Direct Conjugate Addition of α,α‐Disubstituted Aldehydes to Nitroalkenes
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Highly enantioselective addition of ketones to nitroolefins catalyzed by new thiourea–amine bifunctional organocatalysts
TL;DR: A new and effective organocatalytic system: primary amine derived chiral thiourea catalyst and AcOH-H2O additive, which converts different ketones to gamma-nitroketones in high yields and enantioselectivities has been described.
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A proline-catalyzed asymmetric Robinson annulation reaction
Tommy Bui,Carlos F. Barbas +1 more
TL;DR: In this paper, a single-step enantioselective synthesis of the Wieland-Miescher ketone (5 ) is presented, and it is shown that l -proline as well as a number of other chiral amines can act as catalysts of both steps of the Robinson annulation reaction.