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Synthesis of Notoamide J: A Potentially Pivotal Intermediate in the Biosynthesis of Several Prenylated Indole Alkaloids.
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In this paper, an efficient total synthesis of notoamide J, a new prenylated indole alkaloid and potential biosynthetic precursor, is described, starting from l-proline and a substituted tryptophan derivative, also employing an oxidation and pinacol rearrangement for the formation of the oxindole in the final step.Abstract:
An efficient total synthesis of notoamide J, a new prenylated indole alkaloid and potential biosynthetic precursor, is described herein. Starting from l-proline and a substituted tryptophan derivative, this synthesis also employs an oxidation and pinacol rearrangement for the formation of the oxindole in the final step.read more
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Marine Indole Alkaloids
Natalie Netz,Till Opatz +1 more
TL;DR: Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors.
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Safety Assessment of 6-Hydroxyindole as Used in Cosmetics:
Christina L. Burnett,Bart Heldreth,Wilma F. Bergfeld,Donald V. Belsito,Ronald A. Hill,Curtis D. Klaassen,Daniel C. Liebler,James G. Marks,Ronald C. Shank,Thomas J. Slaga,Paul W. Snyder,F. Alan Andersen +11 more
TL;DR: The Panel considered relevant animal and human data provided in this safety assessment and concluded that 6-hydroxyindole is safe for use in oxidative hair dye formulations.
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Journal ArticleDOI
Synthesis of notoamide J: a potentially pivotal intermediate in the biosynthesis of several prenylated indole alkaloids.
TL;DR: An efficient total synthesis of notoamide J, a new prenylated indole alkaloid and potential biosynthetic precursor, is described herein.