Journal ArticleDOI
Synthesis of unsymmetrical methylene derivatives of benzopyran-4-ones from mannich bases
TLDR
In this paper, the formation of methylene-bis derivatives of benzopyran-4-ones from their Mannich bases was studied, and unsymmetrical methylene derivatives were synthesized by reacting Mannich base of BN with structurally related compounds lacking the dialkylaminomethyl group.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2001-03-01. It has received 6 citations till now. The article focuses on the topics: Benzopyran & Methylene.read more
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Journal ArticleDOI
Antiviral activity of indole derivatives
TL;DR: The lack of activity of Mannich bases 4 demonstrates the crucial importance for antiviral activity of coumarin moiety present in Mannichbase 1, while the unsymmetrical methylene derivatives 5 showed a significant activity against RSV.
Journal ArticleDOI
Inhibition of neutrophil O2− production by unsymmetrical methylene derivatives of benzopyrans: their use as potential antiinflammatory agents
TL;DR: Some unsymmetrical derivatives of benzopyrans 9, bearing an acetoxy group in position 7 of the chromone moiety, seem to counteract the neutrophil activation efficiently and reduce the O(2)(-) production by activated human neutrophils.
Journal ArticleDOI
Nickel(II) Complexes with Polyhydroxybenzaldehyde and O,N,S tridentate Thiosemicarbazone ligands: Synthesis, Cytotoxicity, Antimalarial Activity, and Molecular Docking Studies
Savina Savir,Jonathan Wee Kent Liew,Indra Vythilingam,Yvonne A. L. Lim,Chun Hoe Tan,Kae Shin Sim,Vannajan Sanghiran Lee,Mohd Jamil Maah,Kong Wai Tan +8 more
TL;DR: A series of Schiff base metal complexes with the formulations [Ni(L1)PPh3]Cl (1), [Ni[L2]PPh2]Cl(2), Ni[L3]P3] (3), and Ni(L4)Pph3](4) were synthesized in this paper, where the complexes are four-coordinated and adopt a square planar geometry.
Journal ArticleDOI
Unsymmetrical methylene derivatives of indoles as antiproliferative agents
TL;DR: Preliminary results report that some of these compounds might be promising potential antiproliferative agents against breast cancer cell lines tested against the MCF7 and MDA-MB-231.
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Synthesis of 3,3′-(1-piperidino)substituted methylene-bis-isoxazoles preventing stimulus-induced leukocytes activation
TL;DR: The rising hydrophobicity in the side-chain of methylene-bis-isoxazoles leads to a distinction in the neutrophil response against the two stimuli, favoring the inhibition of the PMA elicited cell activation and leaving inaffected the f-MLP induced cell responses.
References
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Journal ArticleDOI
Notes. Researches in the Field of Antiviral Compounds. Mannich Bases of 3-Hydroxycoumarin
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Condensation of Phenols with Amines and Formaldehyde
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Synthesis and antiplatelet activity of 2-(diethylamino)-7-ethoxychromone and related compounds
Mauro Mazzei,Enzo Sottofattori,M Di Braccio,Alessandro Balbi,Giuliana Leoncini,Enrica Buzzi,M. Maresca +6 more
TL;DR: In this paper, the 2-(diethylamino)-7-ethoxychromone 3a and its 2-(1-piperidinyl)analogue 3b were synthesized by reaction of 3-ethoxyphenol 1 with 3-oxo-propanoic acid ethyl ester 2 in the presence of phosphorus oxychloride.
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Research on pyranes, their analogs, and related compounds
TL;DR: In this article, 4, 4-Dichorochromene (I) and 3, 4,4-trichlorochromenes (II) are prepared, and their reactions with nucleophilic reagents (water and aromatic amines) investigated.
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Research on pyranes, their analogs, and related compounds: XXVII. 2-Acylamino-3-dialkylaminomethylchromones and 3, 3'-methylenebis-(2-acylaminochromone)s
TL;DR: By the reaction of 2- acylaminochromones with formaldehyde and secondary amines, a hypothesis concerning the fine structure of these compounds has been put forward as mentioned in this paper.