Systematic review and meta-analysis concerning near-infrared imaging with fluorescent agents to identify the sentinel lymph node in oncology patients
Bernadette Jeremiasse,C.H. van den Bosch,M.W.H.A. Wijnen,C.E.J. Terwisscha van Scheltinga,Marta Fiocco,Marta Fiocco,A.F.W. van der Steeg +6 more
TLDR
Indocyanine green (ICG) as fluorescent agent provides a higher detection rate compared to blue dye for the SNP in a range of different tumor types, and a combination of both ICG and a radio-colloid is suggested.Abstract:
Sentinel node procedures (SNP) are performed with the use of tracer-agents, mainly radio-colloid and/or blue dye. Fluorescent agents have emerged as a new tracer-agent to identify the SLN intra-operatively with near-infrared imaging. Our aim is to compare the detection rate of fluorescent agents to current “golden standards” (blue dye and/or radio-colloid) for the SNP by means of a systematic review and meta-analysis without any restrictions based on tumor type. A systematic search in PubMed, Embase and The Cochrane Library was performed. Articles that compared the detection rates of fluorescent agents with radio-colloid and/or blue dye were included. Meta-analyses were performed for breast, gynecological and dermatological cancer using a random effects model. In total 6195 articles were screened which resulted in a final inclusion of 55 articles. All studies used indocyanine green (ICG) as fluorescent agent. Meta-analyses comparing ICG with blue dye showed a significant and clinically relevant difference in detection rate in favor of ICG, for both breast, dermatological and gynecological cancer. Meta-analyses comparing ICG with radio-colloid did not show any significant differences, with the exception of ICG versus radio-colloid + blue dye for the bilateral SLN detection in gynecological cancer. Near-infrared fluorescence imaging using ICG provides a higher detection rate compared to blue dye for the SNP in a range of different tumor types. SLN detection rates of ICG are comparable to radio-colloid. Due to their complementary characteristics in terms of spatial resolution and transdermal sensitivity, we suggest to use a combination of both ICG and a radio-colloid.read more
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How molecular imaging will enable robotic precision surgery : The role of artificial intelligence, augmented reality, and navigation.
Thomas Wendler,Fijs W. B. van Leeuwen,Fijs W. B. van Leeuwen,Nassir Navab,Nassir Navab,Matthias N. van Oosterom,Matthias N. van Oosterom +6 more
TL;DR: In this article, the authors discuss technologies based on their role at different steps of the surgical workflow, i.e., from surgical decision and planning, over to target localization and excision guidance, all the way to (back table) surgical verification.
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Fluorescence-guided lymph node sampling is feasible during up-front or delayed nephrectomy for Wilms tumor.
TL;DR: Fluorescence-guided lymphatic mapping of Wilms tumor drainage is feasible by both intra-parenchymal (IP) injection and Peri-Hilar (PH) injection as discussed by the authors .
Journal ArticleDOI
Phosphorylcholine-conjugated gold-molecular clusters improve signal for Lymph Node NIR-II fluorescence imaging in preclinical cancer models
Ani Baghdasaryan,Feifei Wang,Fuqiang Ren,Zhuoran Ma,Jiachen Li,Xueting Zhou,Lilit Grigoryan,Chun Xu,Hongjie Dai +8 more
TL;DR: In this article , the authors developed gold molecular clusters (Au 25 ) functionalized by phosphorylcholine (PC) ligands for NIR-II (1000-3000 nm) fluorescence imaging of draining lymph nodes in 4T1 murine breast cancer and CT26 colon cancer tumor mouse models.
Journal ArticleDOI
Indocyanine green versus technetium-99m with blue dye for sentinel lymph node detection in early-stage cervical cancer: A systematic review and meta-analysis
Ilse G. T. Baeten,Jacob P. Hoogendam,Bernadette Jeremiasse,Arthur J. A. T. Braat,Wouter B. Veldhuis,Geertruida N. Jonges,Ina M. Jürgenliemk-Schulz,Carla H. van Gils,Ronald P. Zweemer,Cornelis G. Gerestein +9 more
TL;DR: In this paper, the differences in overall and bilateral SLN detection rates with ICG versus the combined approach, the radiotracer technetium-99m (99m Tc) with blue dye were assessed.
Journal ArticleDOI
Sentinel lymph node assessment in breast cancer—an update on current recommendations
TL;DR: Sentinel lymph node biopsy (SLNB) has become the preferred method of surgical pathological nodal staging of early breast cancer by the end of the nineties as mentioned in this paper, and indeed gross sectioning, step-sectioning, immunohistochemistry, and molecular staging methods have been used to disclose metastatic involvement of these lymph nodes.
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