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Taxol interaction with DNA and RNA: Stability and structural features
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TLDR
Taxol (paclitaxel) is an anticancer drug that interacts with microtubule proteins in a manner that catalyzes their formation from tubulin and stabilizes the resulting structures.Abstract:
Taxol (paclitaxel) is an anticancer drug that interacts with microtubule proteins in a manner that catalyzes their formation from tubulin and stabilizes the resulting structures. However, in the hu...read more
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Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment
Tao Zhang,Taoran Tian,Ronghui Zhou,Songhang Li,Wenjuan Ma,Yuxin Zhang,Nanxin Liu,Sirong Shi,Qianshun Li,Xueping Xie,Yichen Ge,Mengting Liu,Qi Zhang,Shiyu Lin,Xiaoxiao Cai,Yunfeng Lin +15 more
TL;DR: These modified TDN-based complexes promote the intracellular uptake and biostability of the delivered molecules, and show promise in the fields of targeted therapy, antibacterial and anticancer treatment and tissue regeneration.
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Functionalizing Framework Nucleic‐Acid‐Based Nanostructures for Biomedical Application
TL;DR: A review of tetrahedral framework nucleic acids (tFNAs) and their potential for biomedical applications can be found in this article , where the authors focus on four key merits of tFNAs.
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An Overview of DNA and RNA Bindings to Antioxidant Flavonoids
TL;DR: The results show intercalated flavonoids can make them strong antioxidants to protect DNA from harmful free radical reactions, and a partial B to A-DNA transition occurs at high drug concentration, while tRNA remains in A-family structure.
Journal ArticleDOI
Curcumin binding to DNA and RNA.
TL;DR: Spectroscopic evidence showed that curcumin binds to the major and minor grooves of DNA duplex and to RNA bases as well as to the back bone phosphate group with overall binding constants, and Fourier transform infrared (FTIR) and UV-visible spectroscopic methods were used to determine the ligand binding modes and the binding constants.
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An overview of structural features of DNA and RNA complexes with saffron compounds: Models and antioxidant activity.
C.D. Kanakis,Petros A. Tarantilis,Christos S. Pappas,J. Bariyanga,H.A. Tajmir-Riahi,Moschos G. Polissiou +5 more
TL;DR: The antioxidant activity of CRT, DMCRT and safranal was tested by the DPPH (2,2-diphenyl-1-picrylhydrazyl) antioxidant activity assay and their IC(50) values were compared to that of well known antioxidants such as Trolox and Butylated Hydroxy Toluene (BHT).
References
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Journal ArticleDOI
A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
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Promotion of microtubule assembly in vitro by taxol
TL;DR: It is reported here that taxol acts as a promoter of calf brain microtubule assembly in vitro, in contrast to plant products such as colchicine and podophyllotoxin, which inhibit assembly.
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Taxol stabilizes microtubules in mouse fibroblast cells.
TL;DR: Taxol inhibited the migration behavior of fibroblast cells, but these cells did not lose their ability to produce mobile surface projections such as lamellipodia and filopodia.
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