Journal ArticleDOI
TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) causes reduction in the low density lipoprotein (LDL) receptor activities in the hepatic plasma membrane of the guinea pig and rat.
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TLDR
Administration of 1 micrograms/kg of 2,3,7,8-tetrachlorodibenzo-p-dioxin to young male guinea pigs was found to cause a significant reduction in binding of low-density lipoprotein (LDL) to its receptor on the hepatic plasma membrane.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1984-01-30. It has received 39 citations till now. The article focuses on the topics: LDL receptor & Lipoprotein.read more
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Association of Urinary Bisphenol A Concentration with Heart Disease: Evidence from NHANES 2003/06
TL;DR: Higher BPA exposure, reflected in higher urinary concentrations of BPA, is consistently associated with reported heart disease in the general adult population of the USA.
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Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction.
TL;DR: It is most likely that the correlation between genetic differences in human or murine CYP1A1 inducibility by polycyclic hydrocarbons or TCDD and increased risk of cancer will be explained by differences in the AHR gene, leading to enhanced tumor promotion (rather than in the CYP 1A1 structural gene).
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The transcriptional signature of dioxin in human hepatoma HepG2 cells.
TL;DR: The results suggest that arriving at a sound understanding of the molecular mechanisms governing the biological outcome of TCDD exposure promises to be orders of magnitude more complicated than might have been previously imagined.
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Association between serum concentrations of persistent organic pollutants and self-reported cardiovascular disease prevalence: results from the National Health and Nutrition Examination Survey, 1999-2002.
TL;DR: The authors' findings need to be carefully interpreted because of the cross-sectional design and use of self-reported CVD, and Prospective studies are needed to clarify these associations.
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Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1.
Alvaro Puga,Daniel W. Nebert +1 more
TL;DR: In cultured cells, proto-oncogene induction by TCDD appears to be independent of the presence of a functional aryl hydrocarbon (Ah) receptor or nuclear translocation protein, and early events that may lead to the elucidation of the molecular basis of T CDD-induced tumor promotion are revealed.
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Journal ArticleDOI
The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
TL;DR: The relatively low density of the lipoproteins was utilized by Lindgren, Elliott, and Gofman to separate them from the other serum proteins by ultracentrifugal flotation, and quantitation was subsequently performed by refractometric methods in the analytical ultracentRifuge.
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HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS: A Biochemical and Fine Structural Study
M. N. Berry,Daniel S. Friend +1 more
TL;DR: Cytoplasmic vacuolization in a small percentage of cells and potassium loss are the only indications of cell injury detected, and the isolated cells are comparable to normal hepatic parenchymal cells in situ in appearance and function.
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2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity
Alan Poland,Joyce C. Knutson +1 more
TL;DR: The toxicity of halogenated aromatic hydrocarbons appears to be due to the sustained expression of a normal cellular regulatory system, of which the author was previously unaware.
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Regulation of plasma cholesterol by lipoprotein receptors
TL;DR: The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man.
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Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.
TL;DR: This paper showed that liver membranes prepared from livers of ethinyl estradiol-treated rats exhibit a 3 to lo-fold increase in saturable binding sites for human lz51-LDL.
Related Papers (5)
2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity
Alan Poland,Joyce C. Knutson +1 more