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Temporal control of puffing activity in polytene chromosomes.
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This article is published in Cold Spring Harbor Symposia on Quantitative Biology.The article was published on 1974-01-01. It has received 617 citations till now. The article focuses on the topics: Polytene chromosome.read more
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The nuclear receptor superfamily: the second decade.
David J. Mangelsdorf,Carl S. Thummel,Miguel Beato,Peter Herrlich,Günther Schütz,Kazuhiko Umesono,Bruce Blumberg,Philippe Kastner,Manuel Mark,Pierre Chambon,Ronald M. Evans +10 more
TL;DR: This research presents a new probabilistic procedure called ‘spot-spot analysis’ to characterize the response of the immune system to the presence of E.coli.
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Steroid Receptor Regulated Transcription of Specific Genes and Gene Networks
TL;DR: Information is provided on how to identify the Steroid Receptors, Receptor Binding Sites, and other mechanisms that aid in the identification of the receptors and their locations in the genome.
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Chromosomal subunits in active genes have an altered conformation
Harold Weintraub,Mark Groudine +1 more
TL;DR: The results indicate that active genes are probably associated with histones in a subunit conformation in which the associated DNA is particularly sensitive to digestion by deoxyribonuclease I.
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Ecdysone-inducible gene expression in mammalian cells and transgenic mice.
TL;DR: Since ecdysone administration has no apparent effect on mammals, its use for regulating genes should be excellent for transient inducible expression of any gene in transgenic mice and for gene therapy.
Journal ArticleDOI
The drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily
Michael R. Koelle,William S. Talbot,William A. Segraves,Michael T. Bender,Peter Cherbas,David S. Hogness +5 more
TL;DR: The steroid hormone ecdysone triggers coordinate changes in Drosophila tissue development that result in metamorphosis and a gene, EcR, is isolated and characterized for a new steroid receptor homolog and it is shown that it encodes an ecDysone receptor.