Temporal redistribution of inhibition over neuronal subcellular domains underlies state-dependent rhythmic change of excitability in the hippocampus.
Peter Somogyi,Linda Katona,Thomas Klausberger,Thomas Klausberger,Bálint Lasztóczi,Bálint Lasztóczi,Tim J. Viney +6 more
TLDR
The behaviour-contingent rhythmic synchronization of neuronal activity is reported by local field potential oscillations in the theta, gamma and sharp wave-related ripple (SWR) frequency ranges and the key inhibitory role of axo-axonic cells is demonstrated.Abstract:
The behaviour-contingent rhythmic synchronization of neuronal activity is reported by local field potential oscillations in the theta, gamma and sharp wave-related ripple (SWR) frequency ranges. In the hippocampus, pyramidal cell assemblies representing temporal sequences are coordinated by GABAergic interneurons selectively innervating specific postsynaptic domains, and discharging phase locked to network oscillations. We compare the cellular network dynamics in the CA1 and CA3 areas recorded with or without anaesthesia. All parts of pyramidal cells, except the axon initial segment, receive GABA from multiple interneuron types, each with distinct firing dynamics. The axon initial segment is exclusively innervated by axo-axonic cells, preferentially firing after the peak of the pyramidal layer theta cycle, when pyramidal cells are least active. Axo-axonic cells are inhibited during SWRs, when many pyramidal cells fire synchronously. This dual inverse correlation demonstrates the key inhibitory role of axo-axonic cells. Parvalbumin-expressing basket cells fire phase locked to field gamma activity in both CA1 and CA3, and also strongly increase firing during SWRs, together with dendrite-innervating bistratified cells, phasing pyramidal cell discharge. Subcellular domain-specific GABAergic innervation probably developed for the coordination of multiple glutamatergic inputs on different parts of pyramidal cells through the temporally distinct activity of GABAergic interneurons, which differentially change their firing during different network states.read more
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Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning
TL;DR: Alteration of the physiological mechanisms supporting SPW‐Rs leads to their pathological conversion, “p‐ripples,” which are a marker of epileptogenic tissue and can be observed in rodent models of schizophrenia and Alzheimer's Disease.
Journal ArticleDOI
Rhythms of the hippocampal network
TL;DR: The current understanding of the origins and the mnemonic functions of hippocampal theta, sharp wave–ripples and gamma rhythms is discussed on the basis of findings from rodent studies and an updated synthesis of their roles and interactions within the hippocampal network is presented.
Journal ArticleDOI
Space in the brain: how the hippocampal formation supports spatial cognition
TL;DR: It is argued that the neuroscience of spatial cognition is emerging as an exceptionally integrative field which provides an ideal test-bed for theories linking neural coding, learning, memory and cognition.
Journal ArticleDOI
CA1 pyramidal cell diversity enabling parallel information processing in the hippocampus.
Ivan Soltesz,Attila Losonczy +1 more
TL;DR: Recent findings supporting a framework in which the hippocampus comprises principal cell subpopulations forming nonuniform parallel circuits that are independently controlled and affect a variety of behaviors are discussed.
References
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Book
The Hippocampus as a Cognitive Map
John O'Keefe,Lynn Nadel +1 more
TL;DR: The amnesic syndrome is presented as an extension of the theory to humans and the role of operators in the locale system is examined.
Journal ArticleDOI
Place navigation impaired in rats with hippocampal lesions.
TL;DR: It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure.
Journal ArticleDOI
The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
TL;DR: Preliminary observations on the behaviour of hippocampusal units in the freely moving rat provide support for this theory of hippocampal function.
Book
Rhythms of the brain
TL;DR: The brain's default state: self-organized oscillations in rest and sleep, and perturbation of the default patterns by experience.
Journal ArticleDOI
The hippocampus as a cognitive map
TL;DR: Introduction to cognitive PDF heidegger and cognitive science PDF group cognitive therapy Group cognitive therapy for addictions handbook of brief cognitive behavioral therapy gurwitschs relevancy for cognitive science, and imagery creativity and discovery a cognitive perspective.