Terahertz sensing in corneal tissues
David B. Bennett,Zachary Taylor,Priyamvada Tewari,Rahul Singh,Martin O. Culjat,Warren S. Grundfest,Daniel J. Sassoon,R. Duncan Johnson,Jean-Pierre Hubschman,Elliott R. Brown +9 more
Reads0
Chats0
TLDR
Comparison of nine corneas hydrated from 79.1% to 91.5% concentration by mass demonstrated an approximately linear relationship between terahertz reflectivity and water concentration, with a monotonically decreasing slope as the frequency increases.Abstract:
This work introduces the potential application of terahertz (THz) sensing to the field of ophthalmology, where it is uniquely suited due to its nonionizing photon energy and high sensitivity to water content. Reflective THz imaging and spectrometry data are reported on ex-vivo porcine corneas prepared with uniform water concentrations using polyethylene glycol (PEG) solutions. At 79% water concentration by mass, the measured reflectivity of the cornea was 20.4%, 14.7%, 11.7%, 9.6%, and 7.4% at 0.2, 0.4, 0.6, 0.8, and 1 THz, respectively. Comparison of nine corneas hydrated from 79.1% to 91.5% concentration by mass demonstrated an approximately linear relationship between THz reflectivity and water concentration, with a monotonically decreasing slope as the frequency increases. The THz-corneal tissue interaction is simulated with a Bruggeman model with excellent agreement. THz applications to corneal dystrophy, graft rejection, and refractive surgery are examined from the context of these measurements.read more
Citations
More filters
Journal ArticleDOI
Biomedical Applications of Terahertz Spectroscopy and Imaging.
TL;DR: The current state of THz spectroscopy and imaging in various biomedical applications ranging from biomolecules, including DNA/RNA, amino acids/peptides, proteins, and carbohydrates, to cells and tissues are reviewed.
Journal ArticleDOI
THz Medical Imaging: in vivo Hydration Sensing
Z. D. Taylor,Rahul Singh,David B. Bennett,Priyamvada Tewari,Colin Kealey,Neha Bajwa,Martin O. Culjat,A. Stojadinovic,Hua Lee,Jean-Pierre Hubschman,Elliott R. Brown,Warren S. Grundfest +11 more
TL;DR: Two promising medical applications of THz imaging are presented: skin burns and cornea and experimental data measuring the hydration of ex vivo porcine cornea under drying is presented demonstrating utility in ophthalmologic applications.
Journal ArticleDOI
Terahertz biophotonics as a tool for studies of dielectric and spectral properties of biological tissues and liquids
O. A. Smolyanskaya,Nikita V. Chernomyrdin,Nikita V. Chernomyrdin,Nikita V. Chernomyrdin,A. A. Konovko,Kirill I. Zaytsev,Kirill I. Zaytsev,Kirill I. Zaytsev,Ilya A. Ozheredov,Olga P. Cherkasova,Olga P. Cherkasova,Maxim Nazarov,Jean-Paul Guillet,Sergei A. Kozlov,Yu. V. Kistenev,Jean-Louis Coutaz,Patrick Mounaix,Vladimir L. Vaks,Joo-Hiuk Son,Hwayeong Cheon,Vincent P. Wallace,Yu. Feldman,Ivan Popov,Anna N. Yaroslavsky,Alexander P. Shkurinov,Alexander P. Shkurinov,Valery V. Tuchin +26 more
TL;DR: In this article, the authors describe the dielectric properties of biological solutions and liquids in the context of terahertz (THz) biophotonics and discuss the methods of sub-wavelength resolution and the problem of THz wave delivery to hard to access tissues and internal organs.
Journal ArticleDOI
The medical application of terahertz technology in non-invasive detection of cells and tissues: opportunities and challenges
Liu Yu,Liu Hao,Liu Hao,Tang Meiqiong,Huang Jiaoqi,Liu Wei,Dong Jinying,Chen Xueping,Fu WeiLing,Zhang Yang +9 more
TL;DR: Terahertz (THz = 1012 Hz) spectroscopy has shown great potential in biomedical research due to its unique features, such as the non-invasive and label-free identification of living cells and medical imaging.
Journal ArticleDOI
Review of Moisture and Liquid Detection and Mapping using Terahertz Imaging
TL;DR: In this article, spatial mapping of moisture and liquid detection by terahertz (THz) imaging is reviewed, and analysis of the moisture content is discussed in terms of a double Debye model for liquid water and effective medium models for the permittivity of the dry and "wet" materials of interest.
References
More filters
Book
Introduction to Radiological Physics and Radiation Dosimetry
TL;DR: Ionizing Radiation Quantities for Describing the Interaction of Ionizing Radiation with Matter Exponential Attenuation Charged-Particle and Radiation Equilibria Absorbed Dose in Radioactive Media Radioactive Decay
Journal ArticleDOI
Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach.
TL;DR: The "normal" central corneal thickness (CCT) value in human corneas was determined based on reported literature values for within-study average CCT values, and the reported impact of physiological variables, contact lens wear, pharmaceuticals, ocular disease, and ophthalmic surgery on CCT was assessed.
Journal ArticleDOI
The structure and transparency of the cornea
TL;DR: The treatment of the problem of transparency and its solution, as given in this paper, have been the subject of a brief preliminary report (Maurice, 1954).
BookDOI
Sensing with terahertz radiation
TL;DR: In this paper, the authors describe the use of photomixers for continuous-wave terahertz radiation and apply them to time domain ranging and scattering in bio-medical applications.
Journal ArticleDOI
Biomedical applications of terahertz technology
E. Pickwell,Vincent P. Wallace +1 more
TL;DR: In this paper, the development of terahertz (THz) technology and a typical system used in biomedical applications is described, considering applications ranging from THz spectroscopy of crystalline drugs to THz imaging of skin cancer.