Open Access
Terminal Galactose as Cancer Recognition Marker: Computing Analysis With Implications of Vicinal Sugars, Linkage and Anomery
Afshan Kaleem,Ahmed Khurshid,Ishtiaq Ahmad,Evelyne Walker-Nasir,Sadia Khan,M. Iqbal Choudhary,Abdul Rauf Shakoori +6 more
TLDR
The role of terminal Gal, inclusive of its anomery, linkage and that of sugar residues vicinal to terminal Gal in oligosaccharide structures of glycoproteins, as an epitope or as a recognition marker in cancer is described.Abstract:
Carbohydrate structures on proteins play vital role as recognition markers in several diseases including cancer. The carbohydrate chains are dramatically altered in cancer cells compared to normal cells, both in structure and quantity. The mucin O-glycans show several cancer associated structures like T- (Gal-GalNAc-Ser/Thr) and Tn-antigen (GalNAc-Ser/Thr). Terminal galactose (Gal) in mucin type O-glycan oligosaccharide structures is known to act as a recognition marker for several cancer-associated lectins like galectin and mistletoe lectins. This study describes the role of terminal Gal, inclusive of its anomery, linkage and that of sugar residues vicinal to terminal Gal in oligosaccharide structures of glycoproteins, as an epitope or as a recognition marker in cancer.read more
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Progressive impairment of motor skill learning in a D-galactose-induced aging mouse model.
TL;DR: Evidence that D-gal impairs motor learning capacity in a time-dependent manner is provided, and chronic administration of D-Gal is a reliable model for the behavioral decline associated with aging is demonstrated.
Journal ArticleDOI
The role of Galactose in human health and disease
TL;DR: By studying the role of specific seterochemical features of galactose (Gal), this work has improved the understanding about the normal physiology and diseases in human bodies.
Lectin Histochemical Study of GalNac and GlcNac Containing Glycoconjugates in Colon Adenocarcinoma
TL;DR: In this paper, the authors proposed a method to solve the problem of unstructured data in the context of data augmentation, which is based on the work of this paper.
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Synthesis and characterization of new galactosylated-based N2O-donors tridentate ligands
Lidiane Cavalcante Castro,Yasmim R. Jaconiano,Tereza Cristina Santos Evangelista,Sabrina Baptista Ferreira,Marciela Scarpellini +4 more
TL;DR: In this paper, the synthesis and characterization of three novel N2O-donor ligands containing the group 4-[1-β-d-2,3,4,6-tetra-O-acetyl-galactosyl)]benzaldehyde are presented.
References
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