The Accumulation of Protoporphyrin IX in Plaque Psoriasis After Topical Application of 5-Aminolevulinic Acid Indicates a Potential for Superficial Photodynamic Therapy
TLDR
It is shown that the characteristic fluorescence emission of protoporphyrin IX increases in intensity within the 6-h period following application of 5-ami-nolevulinic acid, suggesting that there is a potential for superficial photodynamic therapy.About:
This article is published in Journal of Investigative Dermatology.The article was published on 1996-07-01 and is currently open access. It has received 70 citations till now. The article focuses on the topics: Protoporphyrin IX & Photodynamic therapy.read more
Citations
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Journal ArticleDOI
5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges.
Qian Peng,Trond Warloe,Kristian Berg,Johan Emelian Moan,Magne Kongshaug,Karl Erik Giercksky,Jahn M. Nesland +6 more
TL;DR: Studies have shown that a higher accumulation of ALA‐derived PpIX in rapidly proliferating cells may provide a biologic rationale for clinical use of ALa‐based PDT and diagnosis, however, no review updating the clinical data has appeared so far.
Journal ArticleDOI
Guidelines for topical photodynamic therapy: report of a workshop of the British Photodermatology Group
Colin A. Morton,S B Brown,S Collins,Sally H. Ibbotson,H Jenkinson,H. Kurwa,K Langmack,K McKenna,Harry Moseley,Anthony D. Pearse,Mark R. Stringer,D K Taylor,G Wong,Lesley E. Rhodes +13 more
TL;DR: Current evidence indicates topical PDT to be effective in actinic keratoses on the face and scalp, Bowen's disease and superficial basal cell carcinomas, and several non‐coherent and coherent light sources are effective in PDT.
Journal ArticleDOI
Anti-microbial photodynamic therapy: useful in the future?
TL;DR: This chapter will focus on some aspects of anti-microbial photodynamic therapy that appear to be promising for dermatological indications and inactivation of pathogenic bacteria within the oral cavity.
Journal ArticleDOI
Antibacterial photodynamic therapy in dermatology.
TL;DR: PDT appears to be endowed with several favourable features for the treatment of localized microbial infections, especially after the advent of cationic photosensitising agents which properly interact with the outer wall at the surface of several types of bacterial and yeast cells, increase their permeability, and allow significant amounts of photosensitizer to be accumulated at the level of the cytoplasmic membrane.
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Photodynamic therapy in dermatology
TL;DR: The fluorescence of ALA-induced porphyrins under a Wood light is highly selective in neoplastic cutaneous tissue and offers a useful technique in detecting and delineating skin tumors with ill-defined borders.
References
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Journal ArticleDOI
Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience.
TL;DR: In the ongoing clinical trial of ALA-induced Pp IX photodynamic therapy, the response rate for basal cell carcinomas following a single treatment has been 90% complete response and 7.5% partial response for the first 80 lesions treated.
Journal ArticleDOI
Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy.
TL;DR: Preclinical studies in experimental animals and human volunteers indicate that ALA can induce a localized tissue-specific photosensitization if administered by intradermal injection, opening the possibility of using ALA-induced PpIX to treat tumors that are too thick or that lie too deep to be accessible to either topical or locally injected ALA.
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Photodynamic Therapy of Nonmelanoma Malignant-tumors of the Skin Using Topical Delta-amino Levulinic Acid Sensitization and Laser Irradiation
Katarina Svanberg,Torsten Andersson,Dick Killander,I Wang,Une Stenram,Stefan Andersson-Engels,Roger Berg,Jonas Johansson,Sune Svanberg +8 more
TL;DR: Eighty basal cell carcinomas, 10 lesions of Bowen's disease, and four lesions of cutaneous T‐cell lymphoma in two patients, were treated with photodynamic laser therapy (PDT), using topical application of the haem precursor δ‐amino levulinic acid (ALA).
Journal ArticleDOI
Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer.
TL;DR: For large areas of Bowen's disease, particularly in anatomically difficult areas and in elderly patients, PDT using ALA may constitute a single simple alternative outpatient treatment to existing therapies.
Journal ArticleDOI
Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid: An alternative treatment modality for solar keratoses, superficial squamous cell carcinomas, and basal cell carcinomas?
Peter Wolf,E. Rieger,Helmut Kerl +2 more
TL;DR: Topical photodynamic therapy with endogenous porphyrins is effective for superficial epithelial skin tumors and only 1 of 10 nodulo-ulcerative basal cell carcinomas completely resolved.
Related Papers (5)
Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid: An alternative treatment modality for solar keratoses, superficial squamous cell carcinomas, and basal cell carcinomas?
Peter Wolf,E. Rieger,Helmut Kerl +2 more