Journal ArticleDOI
The activity of class I, II, III, and IV alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in liver cancer.
TLDR
Differences in the activities of total ADH, ALDH and class I ADH isoenzyme between cancer liver tissues and healthy hepatocytes might be a factor in ethanol metabolism disorders, which can intensify carcinogenesis.Abstract:
Background/Aims Ethanol consumption is associated with an increased risk of esophageal cancer. The carcinogenic compound is acetaldehyde, the product of ethanol metabolism. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are the main enzymes involved in ethanol metabolism, which leads to generation of acetaldehyde. In this study the activity of ADH isoenzymes and ALDH in esophageal cancer were compared with the activity in normal tissue. Methods For measurement of the activity of class I and II ADH isoenzymes and ALDH activity fluorimetric methods were employed. Total ADH activity and activity of class III and IV isoenzymes was measured by the photometric method. Samples were taken from 59 esophageal cancer patients (27 adenocarcinoma, 32 squamous cell cancer). Results The total activity of ADH and activity of class IV ADH were significantly higher in cancer cells than in healthy tissues. The other tested classes of ADH showed a tendency toward higher activity in cancer than in normal cells. Differences between the activity of enzymes of drinkers and non-drinkers in both cancer and healthy tissue were not significant. Conclusion Increased ADH IV activity may be a factor intensifying carcinogenesis, because of the increased ability to form acetaldehyde from ethanol.read more
Citations
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Journal ArticleDOI
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the cancer diseases
TL;DR: Significant differences of ADH isoenzymes activities between cancer tissues and healthy organs may be a factor intensifying carcinogenesis by the increased ability to acetaldehyde formation from ethanol and disorders in metabolism of some biologically important substances.
Journal ArticleDOI
Mechanisms of Gastroprotective Effects of Ethanolic Leaf Extract of Jasminum sambac against HCl/Ethanol-Induced Gastric Mucosal Injury in Rats.
Ahmed S. AlRashdi,Suzy M. Salama,Salim S. Alkiyumi,Mahmood Ameen Abdulla,A. Hamid A. Hadi,Siddig Ibrahim Abdelwahab,Manal Mohamed Elhassan Taha,Jamal Hussiani,Nur Asykin +8 more
TL;DR: Significant increased in the pH, mucus of gastric content and high levels of PGE2, SOD and reduced amount of MDA was observed and the plant promotes ulcer protection as it shows significant reduction of ulcer area grossly.
Journal ArticleDOI
Alcohol and Cancer: Mechanisms and Therapies.
Anuradha Ratna,Pranoti Mandrekar +1 more
TL;DR: Insight is provided into cancer pathogenesis in alcoholics, alcohol and immune interactions in different cancers, and scope and future of targeted immunotherapeutic modalities in patients with alcohol abuse.
Journal ArticleDOI
ALDH as a Stem Cell Marker in Solid Tumors
Mariel E. Toledo-Guzmán,Miguel Ibanez Hernandez,Ángel A Gómez-Gallegos,Elizabeth Ortiz-Sánchez +3 more
TL;DR: The controversy of ALDH activity to maintain CSC stemness, or conversely, to promote cell differentiation, is discussed, and the advances in using ALDH inhibitors as an anti-cancer drugs are reviewed.
Journal ArticleDOI
Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians
TL;DR: New health appraisal models that include ALDH2 genotype, the simple flushing questionnaire, or MCV are powerful tools for devising a new strategy for prevention and screening for UADT cancer in East Asians.
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