Journal ArticleDOI
The anti-inflammatory action of heparin: Heparin as an antagonist to histamine, bradykinin and prostaglandin E1
TLDR
Heparin at a dose of 50–100 units/kg intravenously will suppress increased vascular permeability induced by logarithmic doses of histamine, bradykinin, and prostaglandin E1, and these findings support the hypothesis that heparin affects the micro-circulation.About:
This article is published in Thrombosis Research.The article was published on 1979-01-01. It has received 66 citations till now. The article focuses on the topics: Heparin & Smooth muscle contraction.read more
Citations
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Book ChapterDOI
Heparin in inflammation: potential therapeutic applications beyond anticoagulation
TL;DR: In vivo data showing heparin's beneficial effects in various preclinical models of inflammatory disease as well as some clinical studies showing that the anti-inflammatory activities ofheparin may translate into therapeutic uses indicate that the anticoagulant activity can be distinguished from hepar in's anti- inflammatory properties.
Journal ArticleDOI
Pharmacology of Heparin and Related Drugs
TL;DR: A “state of the art” review of the current understanding of the pharmacology of heparin and related drugs and an overview of the status of development of such drugs are provided.
Journal ArticleDOI
Heparin in the treatment of burns: a review.
TL;DR: Heparin therapy of burns may be a useful addition to the range of available treatments for burn wounds as discussed by the authors, which may stimulate tissue repair and reepithelializing effects.
Journal ArticleDOI
Heparin Inhibits the Immediate Response to Antigen in the Skin and Lungs of Allergic Subjects
TL;DR: It is demonstrated that a small dose of heparin administered intravenously 10 min before challenge reduced the acute cutaneous reaction to 10 allergens and histamine from a group-average sum of mean (+/- SD) wheal diameters at a baseline of 29.9 +/- 10 mm and after normal saline placebo.
Journal ArticleDOI
Heparin attenuates TNF-alpha induced inflammatory response through a CD11b dependent mechanism.
Antonio Salas,Miquel Sans,Alex Soriano,Joan Carles Reverter,D C Anderson,J M Piqué,Julián Panés +6 more
TL;DR: The results support the concept that the anti-inflammatory effects of heparin involve attenuation of a CD11b dependent adherent mechanism.
References
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Journal ArticleDOI
Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs
TL;DR: The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.
Journal ArticleDOI
STUDIES ON INFLAMMATION: I. The Effect of Histamine and Serotonin on Vascular Permeability: An Electron Microscopic Study
Guido Majno,G. E. Palade +1 more
TL;DR: The mechanism, whereby histamine and serotonin increase the permeability of blood vessels, was studied in the rat by means of the electron microscope, and electron microscopic findings suggested that the endothelial cells become partially disconnected along the intercellular junctions.
Journal ArticleDOI
Vascular reactions to histamine, histamine-liberator and leukotaxine in the skin of guinea-pigs.
A. A. Miles,E. M. Miles +1 more
TL;DR: The present investigation is part of an attempt to prove an old hypothesis, namely, that this increase in permeability is mediated by histamine, and is confined to the skin of guinea-pigs.
Journal ArticleDOI
New Aspects of the Mode of Action of Nonsteroid Anti-Inflammatory Drugs
S. H. Ferreira,J. R. Vane +1 more
TL;DR: This review surveys recent work on the possible mode of action and on the effects of that group of drugs variously known as non-narcotic analgesics, nonsteroidal anti-inflammatory drugs, aspirin-like drugs, antiphlogistic acids, and so on.
Journal ArticleDOI
The observation of heparin on endothelium after injection.
Linda M. Hiebert,L.B. Jaques +1 more
TL;DR: An electron micrograph of preparations stained with Ruthenium Red taken at five minutes after intravenous injection of heparin demonstrated a marked increase in electron density, as compared to normal endothelium, at the cell membrane and in vesicles near the luminal surface of the cell.