Journal ArticleDOI
The case for blood pressure control in risk groups
Luis M. Ruilope,Massimo Volpe +1 more
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TLDR
The completion of one of the most important trials undertaken to explore risk factors and anti‐hypertensive treatment, the Valsartan long‐term evaluation trial (VALUE), will certainly enhance understanding for the role of combination treatment in high‐risk patients, as well as contribute to the design of rational treatments for blood pressure control.Abstract:
Hypertension rarely occurs in isolation, and many hypertensives have additional risk factors for cardiovascular disease in addition to elevated blood pressure. Each patient's cardiovascular disease risk profile should be determined individually, and the treatment approach tailored to each case. Cardiovascular disease risk factors and high blood pressure are closely linked, suggesting that the ideal treatment should not only lower blood pressure, but also effectively lower overall risk. This is likely to require more than one drug, and one of the most effective and safe combinations is that of an angiotensin receptor blocker with a diuretic. The completion of one of the most important trials undertaken to explore risk factors and anti-hypertensive treatment, the Valsartan long-term evaluation trial (VALUE), will certainly enhance understanding for the role of combination treatment in high-risk patients, as well as contribute to the design of rational treatments for blood pressure control.read more
Citations
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Journal ArticleDOI
K036: Left ventricular geometry and function in patients with essential hypertension and microalbuminuria
Roberto Pontremoli,Maura Ravera,C. Nicolella,Francesca Viazzi,Valeria Berruti,Giovanna Leoncini,G.P. Bezante,P. Zagami,N. Ruello,Cinzia Tomolillo,Giacomo Deferrari +10 more
TL;DR: The findings strengthen the role of microalbuminuria as an indicator of subclinical cardiovascular disease and may account for the worse outcome that is usually associated with increased urinary albumin excretion in essential hypertension.
Journal ArticleDOI
Managing hypertension in cardiology practice according to risk profile
Massimo Volpe,Giuliano Tocci +1 more
TL;DR: The concept of treating hypertension using a global risk assessment approach is examined and effective hypertensive therapy as part of global risk management in patients typically seen in cardiology practice is proposed.
Journal ArticleDOI
Managing hypertension in high-risk patients: lessons and promises from the STRATHE and ADVANCE trials.
TL;DR: Using the perindopril–indapamide combination to initiate antihypertensive therapy has been shown in a double-blind trial to normalize blood pressure in significantly more patients than a sequential monotherapy approach based on atenolol, losartan and amlodipine and a stepped-care strategy based on valsartan
Journal ArticleDOI
Can the effectiveness of hypertension management be improved
TL;DR: Some of the challenges of hypertension management are discussed and strategies and treatment advances that may pave the way to more effective BP control are reviewed.
Journal ArticleDOI
Are there new threshold and goals in the treatment of arterial hypertension
Julian Segura,Luis M. Ruilope +1 more
TL;DR: A review of the controversies and challenges involved in the treatment of patients with established arterial hypertension, such as the progression of high-normal BP to overt hypertension, the choice of appropriate threshold and goal BP levels, the adequate number of drugs to be used since the early stages of hypertension, and which type of combination therapy offers most advantages to the patient is presented in this paper.
References
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Journal ArticleDOI
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.
Aram V. Chobanian,George L. Bakris,Henry R. Black,William C. Cushman,Lee A. Green,Joseph L. Izzo,Daniel W. Jones,Barry J. Materson,Suzanne Oparil,Jackson T. Wright,Edward J. Roccella +10 more
TL;DR: The most effective therapy prescribed by the most careful clinician will control hypertension only if patients are motivated, and empathy builds trust and is a potent motivator.
Journal ArticleDOI
Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
Aram V. Chobanian,George L. Bakris,Henry R. Black,William C. Cushman,Lee A. Green,Joseph L. Izzo,Daniel W. Jones,Barry J. Materson,Suzanne Oparil,Jackson T. Wright,Edward J. Roccella +10 more
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Journal Article
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Journal ArticleDOI
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
Barry M. Brenner,Mark E. Cooper,Dick de Zeeuw,William F. Keane,William E. Mitch,Hans-Henrik Parving,Giuseppe Remuzzi,Steven M. Snapinn,Zhonxin Zhang,Shahnaz Shahinfar +9 more
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