Journal ArticleDOI
The effect of neurotensin on food consumption in the rat
Daniel Luttinger,Richard A. King,David Sheppard,John Strupp,Charles B. Nemeroff,Arthur J. Prange +5 more
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TLDR
Acute intracerebroventricular injection of neurotensin shortly after the ingestion of a novel flavor did not produce a flavor aversion during testing 48 h later, suggesting that reduction of food intake by low doses of centrally administered neurotens in rats is not related to a conditioned taste aversion.About:
This article is published in European Journal of Pharmacology.The article was published on 1982-07-16. It has received 128 citations till now. The article focuses on the topics: Neurotensin & Taste aversion.read more
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Characterization of CART neurons in the rat and human hypothalamus.
Carol F. Elias,Charlotte E. Lee,Joseph Kelly,Rexford S. Ahima,Michael J. Kuhar,Clifford B. Saper,Joel K. Elmquist +6 more
TL;DR: The results indicate that leptin directly acts on CART neurons in distinct nuclei of the rat hypothalamus and the distribution of CART cell bodies and fibers in the human hypothalamus indicates that CART may also play a role in the regulation of energy homeostasis in humans.
Journal ArticleDOI
Chemical characterization of leptin-activated neurons in the rat brain.
Carol F. Elias,Carol F. Elias,Joseph Kelly,Charlotte E. Lee,Rexford S. Ahima,Daniel J. Drucker,Clifford B. Saper,Joel K. Elmquist +7 more
TL;DR: In this article, the authors explored systematically the distribution of leptin-activated neurons throughout the rat brain and investigated the chemical identity of subsets of these leptinactivated cells, and found that leptin stimulates brain pathways containing neuropeptides that are involved in the regulation of energy balance, autonomic homeostasis, and neuroendocrine status.
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Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance.
TL;DR: It is hypothesize that defective regulation of PI3K-PDE3B-cAMP pathway may be one of the mechanisms behind the development of central leptin resistance seen in obesity.
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Neuropeptides, food intake and body weight regulation: a hypothalamic focus
TL;DR: In this review the role of several anorexigenic and orexigenic neuropeptides on food intake and body weight regulation is summarized.
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The lateral hypothalamus as integrator of metabolic and environmental needs: from electrical self-stimulation to opto-genetics.
H.-R. Berthoud,Heike Münzberg +1 more
TL;DR: Recent progress in understanding the role of the lateral hypothalamic area in the control of ingestive behavior and the regulation of energy balance is reviewed.
References
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Journal ArticleDOI
Bombesin suppresses feeding in rats.
TL;DR: It is shown that BBS also suppresses food intake, and its action with that of CCK is compared.
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Central nervous system action of bombesin: mechanism to induce hyperglycemia.
TL;DR: The data support the conclusion that bombesin acts within the brain to increase sympathetic outflow resulting in increased adrenalmedullary epinephrine secretion, followed by depression of plasma insulin and elevation of plasma glucagon and glucose.
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Effects of neurotensin and substance P on plasma insulin, glucagon and glucose levels.
Marvin R. Brown,Wylie Vale +1 more
TL;DR: The enhanced glucogenic effects of neurotensin and substance P over glucagon may well result from their inhibition of insulin release and may be important in glucose homeostasis.
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Conditioned taste aversions: Two-stimulus tests are more sensitive than one-stimulus tests
TL;DR: Following exposure to saccharin, rats were injected with 0, 21, or 37 mg/kg of cyclophosphamide, which had a highly significant effect in two-stimulus tests and had no significant effect on Saccharin preference in one- Stimulus tests.