Journal ArticleDOI
The effect of prolonged lithium administration on cerebral monoamine neurons in the rat.
Hans Corrodi,Hans Corrodi,Hans Corrodi,Kjell Fuxe,Kjell Fuxe,Kjell Fuxe,Mogens Schou,Mogens Schou,Mogens Schou +8 more
TLDR
Noradrenaline, dopamine and 5-hydroxytryptamine were determined chemically and histochemically in the brains of rats given lithium with the food for three weeks, indicating that prolonged administration of small lithium doses leads to a lowering of the activity in 5- Hydroxytryptamines neurons or an inhibition of the impulse-stimulated release of 5-Hydroxyt Kryptamine at the nerve terminals.About:
This article is published in Life Sciences.The article was published on 1969-06-01. It has received 89 citations till now. The article focuses on the topics: Tyrosine Hydroxylase Inhibitor & Tyrosine hydroxylase.read more
Citations
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Book ChapterDOI
Morphological and Functional Aspects of Central Monoamine Neurons
TL;DR: The Nigro–Neostriatal neurons perform both the motor and mental functions and the central 5-hydroxytryptamine neurons contribute to the function in mood, wakefulness, thought process, behavior, neuroendocrine function, and function in reflex activity.
Journal ArticleDOI
Dopamine and mania: Behavioral and biochemical effects of the dopamine receptor blocker pimozide
TL;DR: In manic patients pimozide produces substantial clinical improvement with a magnitude and time course similar to that observed with the more routinely used phenothiazines chlorpromazine and thioridazine.
Journal ArticleDOI
Lithium for Cluster Headache: Review of the Literature and Preliminary Results of Long‐term Treatment
TL;DR: In this paper, 19 male patients aged 26 to 67 years have been treated with lithium sulphate in the form of slow release tablets (Lithionit(r) Durules(r)) to prevent attacks of cluster headache.
Journal ArticleDOI
The effect of prolonged lithium treatment on the synthesis rate and turnover of monoamines in brain regions of rats
TL;DR: There may be a variable relationship between the tissue concentration and synthesis rates of the monoamines under both normal conditions and lithium treatment, and the observed differences in the action of lithium on monoamines in the regions studied may be related to the morphology of these discrete areas.
References
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Journal ArticleDOI
Fluorescence of Catechol Amines and Related Compounds Condensed With Formaldehyde
TL;DR: In this article, the reaction between formaldehyde and phenylalanine and phenylethylamine derivatives has been studied under mild conditions and it has been shown that the amines primarily condense with formaldehyde to 1,2,3,4-tetrahydroisoquinolines which are involved in a secondary reaction to become highly fluorescent and at the same time insoluble.
Journal ArticleDOI
A Method for the Fluorimetric Determination of Adrenaline and Noradrenaline in Tissues.1
TL;DR: A method for chemical assay of small amounts of adrenaline and noradrenaline in tissues is described, utilizing the difference in the activation spectra of the fluoro-phores to identify the two amines.
Journal ArticleDOI
The formaldehyde fluorescence method for the histochemical demonstration of biogenic monoamines a review on the methodology
Hans Corrodi,Gösta Jonsson +1 more
TL;DR: The histochemical fluorescence method of Falck and Hillarp as discussed by the authors for the demonstration of biogenic monoamines is based on the finding that the amines can be condensed with formaldehyde to yield strongly fluorescent compounds, provided that they are enclosed in a dried protein layer, as in freezedried or air-dried tissues.
Journal ArticleDOI
In‐Vivo Decarboxylation of α‐Methyl DOPA and α‐Methyl Metatyrosine
Arvid Carlsson,Margit Lindqvist +1 more
TL;DR: In this paper, α-Methyl DOPA (DOPA = 3,4-dihydroxyphenylalanine) and α-methyl metatyrosine were injected to mice (400 mg/kg intraperitoneally).
Journal ArticleDOI
Lithium in psychiatric therapy and prophylaxis.
TL;DR: An up-to-date, critical assessment of psychiatric lithium therapy and prophylactic action against endogenous affective disorder, including manic-depressive disorder and recurrent endogenous depressions is presented.