Journal ArticleDOI
The effects of ACTH, adrenalectomy and dexamethasone on the acquisition of an avoidance response in rats.
TLDR
The action of ACTH on avoidance conditioning is clearly extra-adrenal, but ACTH is not essential to normal performance, at least when high levels of glucocorticoids are present.About:
This article is published in Physiology & Behavior.The article was published on 1970-08-01. It has received 75 citations till now. The article focuses on the topics: ACTH inhibitor & Avoidance response.read more
Citations
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Book ChapterDOI
Lipotropin and the central nervous system.
TL;DR: This chapter deals with the interaction of the lipotropin fragments and related peptides with the central nervous system (CNS) and the differences known to exist between the two classes of LPH fragments.
Journal ArticleDOI
Prenatal dexamethasone exposure in rats : effects of dose, age at exposure, and drug-induced hypophagia on malformations and fetal organ weights
TL;DR: Pair-feeding experiments suggested that the hypophagic effect of DEX was not responsible for the noted malformations and had little impact on growth stunting, and the brain, heart, testes, and long bones were relatively resistant to DEX.
Journal ArticleDOI
Possible significance of ACTH fragments for human mental performance.
TL;DR: Results of experiments with rats indicate that ACTH 4–10 and other fragments or analogs that are devoid of endocrine effects have an effect on acquisition and delay extinction of conditioned behavior and a facilitating effect on retrieval from memory.
Journal ArticleDOI
Reversal of amnesia by an orally active ACTH 4-9 analog (Org 2766).
TL;DR: It is suggested that ACTH-like peptides, and particularly the orally active Org 2766, may be helpful in the treatment of deficient mental performance.
Journal ArticleDOI
Diurnal cycle and ACTH facilitation of shuttlebox avoidance.
TL;DR: The results mimic the effects of septal or hippocampal lesions in shuttlebox and are viewed as consistent with the hypothesis that the lesion results are due to a hormonally mediated mechanism.
References
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Journal ArticleDOI
Some Studies of the Protein-Binding of Steroids and Their Application to the Routine Micro and Ultramicro Measurement of Various Steroids in Body Fluids by Competitive Protein-Binding Radioassay
TL;DR: A 100-fold increase in sensitivity has now been achieved by using tritiated steroids in place of 14C-labeled steroids, by utilizing the CBG's of species other than man, and by using adsorption in Place of dialysis or gel filtration.
Journal ArticleDOI
Fluorometric Determination of Corticosterone and Cortisol in 0.02–0.05 Milliliters of Plasma or Submilligram Samples of Adrenal Tissue1
Journal ArticleDOI
Long Term and Short Term Effects on Retention of a Conditioned Avoidance Response in Rats by Treatment with Long Acting Pitressin and α-MSH
D. de Wied,B. Bohus +1 more
TL;DR: It is found that the rapid extinction of a CAR which occurs after posterior lobectomy or hypophysectomy can be prevented by treatment with ACTH, melanocyte stimulating hormone (α-MSH) or lysine vasopressin given during the extinction period.
Journal ArticleDOI
Inhibitory Effect of ACTH and Related Peptides on Extinction of Conditioned Avoidance Behavior in Rats
TL;DR: ACTH, administered during extinction, delays extinction of an avoidance response in rats and results were interpreted to indicate that the active part of ACTH in this respect is located in the N-terminal part of the molecule, presumably in the first 10 amino acids.
Journal ArticleDOI
Influence of anterior pituitary on avoidance learning and escape behavior.
TL;DR: Adenohypophysectomized rats were subjected to an avoidance learning procedure and only 6 of 21 rats achieved the conditioning criterion against 14 of 18 sham-operated controls.
Related Papers (5)
Inhibitory Effect of ACTH and Related Peptides on Extinction of Conditioned Avoidance Behavior in Rats
The effect of adrenocorticotrophic hormone (ACTH) on avoidance conditioning in the rat.
Murphy Jv,Miller Re +1 more