Journal ArticleDOI
The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
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It is demonstrated that nanocurcumin intake in patients with DFU resulted in a significant improvement of glycemic control, total‐ and LDL‐cholesterol, TAC, and GSH but did not affect the indicators of ulcer size.Abstract:
This study was conducted to determine the effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double-blind, placebo-controlled trial was conducted among 60 patients with grade 3 DFU. Participants were randomly allocated into two groups (30 participants each group), received either 80 mg nanocurcumin daily for 12 weeks or placebo. Primary endpoints in this study were serum insulin levels and insulin resistance. Curcumin intake significantly decreased fasting plasma glucose (p = .02), insulin (p = .01), insulin resistance (p = .02), and significantly increased insulin sensitivity (p = .008) compared with the placebo. Moreover, curcumin intake led to a significant reduction in total- (p < .001), LDL-cholesterol (p < .001), and a significant increase in total antioxidant capacity (TAC) (p < .001) and total glutathione (GSH) (p = .01) compared with the placebo. However, there was no significant improvement in wound healing parameters. Overall, our study demonstrated that nanocurcumin intake in patients with DFU resulted in a significant improvement of glycemic control, total- and LDL-cholesterol, TAC, and GSH but did not affect the indicators of ulcer size.read more
Citations
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The Effects of Curcumin on Diabetes Mellitus: A Systematic Review.
Ledyane Taynara Marton,Laís Maria Pescinini-e-Salzedas,Maria Eduarda Côrtes Camargo,Sandra Maria Barbalho,Jesselina Francisco dos Santos Haber,Renata Vargas Sinatora,Cláudia Rucco Penteado Detregiachi,Raul José Silva Girio,Daniela Vieira Buchaim,Patrícia Cincotto dos Santos Bueno +9 more
TL;DR: In this article, the effects of Curcuma longa or curcumin on patients with Type II diabetes mellitus were systematically reviewed, and the final selection included sixteen studies that fulfilled the inclusion criteria.
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Mitophagy and mitochondrial dynamics in type 2 diabetes mellitus treatment
TL;DR: The role of mitophagy in type 2 diabetes relevant diseases and the pharmacological basis and therapeutic potential of autophagy regulators in type 1 diabetes are focused on.
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Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?
Mangala Gowri Hegde,Sosmitha Girisa,Bandari BharathwajChetty,Ravichandran Vishwa,Ajaikumar B. Kunnumakkara +4 more
TL;DR: In this article , the authors extensively reviewed clinical trials on various generations of curcumin formulations and their safety and efficacy in the treatment of many diseases and summarized the dose, duration, and mechanism of action of these formulations.
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Downregulated hs-CRP and MAD, upregulated GSH and TAC, and improved metabolic status following combined exercise and turmeric supplementation: a clinical trial in middle-aged women with hyperlipidemic type 2 diabetes
TL;DR: In this article , the effects of AT and Turmeric Supplementation (TS) on metabolic status and oxidative stress biomarkers related to inflammation in subjects with Type 2 Diabetes Mellitus (HT2DM) were evaluated.
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Journal Article
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