The European Centre for Disease Prevention and Control (ECDC) pilot point prevalence survey of healthcare-associated infections and antimicrobial use
Peter Zarb,Peter Zarb,Bruno Coignard,J Griskeviciene,Arno Muller,Vanessa Vankerckhoven,Klaus Weist,M. Goossens,S. Vaerenberg,Susan Hopkins,Boudewijn Catry,Dominique L Monnet,Herman Goossens,Carl Suetens +13 more
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A standardised methodology for a combined point prevalence survey (PPS) on healthcare-associated infections (HAIs) and antimicrobial use in European acute care hospitals developed by the European Centre for Disease Prevention and Control was piloted across Europe.Abstract:
A standardised methodology for a combined point prevalence survey (PPS) on healthcare-associated infections (HAIs) and antimicrobial use in European acute care hospitals developed by the European Centre for Disease Prevention and Control was piloted across Europe. Variables were collected at national, hospital and patient level in 66 hospitals from 23 countries. A patient-based and a unit-based protocol were available. Feasibility was assessed via national and hospital questionnaires. Of 19,888 surveyed patients, 7.1% had an HAI and 34.6% were receiving at least one antimicrobial agent. Prevalence results were highest in intensive care units, with 28.1% patients with HAI, and 61.4% patients with antimicrobial use. Pneumonia and other lower respiratory tract infections (2.0% of patients; 95% confidence interval (CI): 1.8–2.2%) represented the most common type (25.7%) of HAI. Surgical prophylaxis was the indication for 17.3% of used antimicrobials and exceeded one day in 60.7% of cases. Risk factors in the patient-based protocol were provided for 98% or more of the included patients and all were independently associated with both presence of HAI and receiving an antimicrobial agent. The patient-based protocol required more work than the unit-based protocol, but allowed collecting detailed data and analysis of risk factors for HAI and antimicrobial use.read more
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Multistate point-prevalence survey of health care-associated infections.
Shelley S. Magill,Jonathan R. Edwards,Wendy Bamberg,Zintars G. Beldavs,Ghinwa Dumyati,Marion A. Kainer,Ruth Lynfield,Meghan Maloney,Joelle Nadle,Susan M. Ray,Deborah L. Thompson,Lucy E. Wilson,Scott K. Fridkin +12 more
TL;DR: Results of this multistate prevalence survey of health care-associated infections indicate that public health surveillance and prevention activities should continue to address C. difficile infections.
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Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review.
Luigi Rizzo,Célia M. Manaia,Christophe Merlin,Thomas Schwartz,Christophe Dagot,Marie-Cécile Ploy,I. Michael,Despo Fatta-Kassinos +7 more
TL;DR: The final objective is to implement wastewater treatment technologies capable of assuring the production of UWTPs effluents with an acceptable level of ARB, to understand the factors and mechanisms that drive antibiotic resistance maintenance and selection in wastewater habitats.
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Antibacterial Coatings: Challenges, Perspectives, and Opportunities
TL;DR: This work reviews release-based antibacterial coatings and highlights recent approaches aimed at controlling the release of antibacterial agents, imparting multi-functionality, and enhancing long-term stability.
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Burden of Six Healthcare-Associated Infections on European Population Health: Estimating Incidence-Based Disability-Adjusted Life Years through a Population Prevalence-Based Modelling Study
Alessandro Cassini,Alessandro Cassini,Diamantis Plachouras,Tim Eckmanns,Muna Abu Sin,Hans-Peter Blank,Tanja Ducomble,Sebastian Haller,Thomas Harder,Anja Klingeberg,Madlen Sixtensson,Enrique Velasco,Bettina Weiß,Piotr Kramarz,Dominique L Monnet,Mirjam Kretzschmar,Carl Suetens +16 more
TL;DR: The main limitations of the study are the variability in the parameter estimates, in particular the disease models’ case fatalities, and the use of the Rhame and Sudderth formula for estimating incident number of cases from prevalence data.
Journal ArticleDOI
Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey.
Ann Versporten,Peter Zarb,Isabelle Caniaux,Marie Francoise Gros,Nico Drapier,Mark Miller,Vincent Jarlier,Dilip Nathwani,Herman Goossens,Andi Koraqi,Iris Hoxha,Silva Tafaj,Denada Lacej,Martin Hojman,Rodolfo Ernesto Quiros,Lilit Ghazaryan,Kelly A. Cairns,Allen C. Cheng,Kylie Horne,Fiona F. Doukas,Thomas Gottlieb,Jameela Alsalman,Koen Magerman,Gounongbe Yt Marielle,Amela Dedeic Ljubovic,André Afonso Machado Coelho,Ana Cristina Gales,Emma Keuleyan,Deana Sabuda,Jennifer Lee Boswell,John M. Conly,Alvaro Rojas,Camila Carvajal,Jaime Labarca,Antonio Solano,Carlos Ramírez Valverde,Juan M. Villalobos-Vindas,Irina Pristaš,Vanda Plecko,Niki Paphitou,Erjona Shaqiri,Maija Liisa Rummukainen,Karaman Pagava,Irma Korinteli,Tobias Brandt,Sabine Messler,Anthony Enimil,Elias Iosifidis,Emmanuel Roilides,Mamadou Saliou Sow,Sharmila Sengupta,Joby V. George,Aruna Poojary,Priyanka Patil,Jafar Soltani,Zahra Jafarpour,Hadi Ameen,David Fitzgerald,Yasmin Maor,Michal Chowers,Elizabeth Temkin,Susanna Esposito,Luca Arnoldo,Silvio Brusaferro,Yoshiaki Gu,Feras Darwish El-Hajji,Nam Joong Kim,Baktygul Kambaralieva,Jana Pavare,Lelde Zarakauska,Vytautas Usonis,Sigita Burokiene,Inga Ivaskeviciene,Gordana Mijovic,Natasa Duborija-Kovacevic,Kristen Bondesio,Kenneth Iregbu,OO Oduyebo,Denis Raka,Lul Raka,Svetlana Rachina,Mushira Enani,Mohamed Al Shehri,Biljana Carevic,Gorana Dragovac,Dusanka Obradovic,Aleksandra Stojadinovic,Lili Radulovic,Jia En Wu,Gladys Wei Teng Chung,Hui Hiong Chen,Paul A. Tambyah,David C. Lye,Sock Hoon Tan,Tat Ming Ng,Hui Lin Tay,Moi Lin Ling,Maciej Piotr Chlebicki,Andrea L. Kwa,Winnie Lee,Bojana Beović,Angela Dramowski,Heather Finlayson,Jantjie Taljaard,Guillermo Ojeda-Burgos,Pilar Retamar,Johan Lucas,Wolter Pot,Cees Verduin,Jan Kluytmans,Michael G. Scott,Mamoon A. Aldeyab,Bernadette McCullagh,Cairine Gormley,David Sharpe,Mark Gilchrist,Laura Whitney,Matthew Laundy,Debbie Lockwood,Simon B. Drysdale,Jennifer Boudreaux,Edward J. Septimus,Nickie Greer,Gerard Gawrys,Edgar Rios,Suzanne May +125 more
TL;DR: Detailed data about antimicrobial prescribing and resistance from hospitals worldwide will help to improve the quality of antibiotic prescribing through education and practice changes, particularly in low-income and middle-income countries that have no tools to monitor antibiotic prescribing in hospitals.
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