scispace - formally typeset
Open AccessPosted Content

The field theoretical ABC of epidemic dynamics

TLDR
In this article, a review of mathematical models of infectious disease diffusion by simultaneously investigating the underlying microscopic dynamics in terms of percolation models, effective description via compartmental models and the employment of temporal symmetries is presented.
Abstract
Infectious diseases are a threat for human health with tremendous impact on our society at large. The recent COVID-19 pandemic, caused by the SARS-CoV-2, is the latest example of a highly infectious disease ravaging the world, since late 2019. It is therefore imperative to develop efficient mathematical models, able to substantially curb the damages of a pandemic by unveiling disease spreading dynamics and symmetries. This will help inform (non)-pharmaceutical prevention strategies. For the reasons above we wrote this report that goes at the heart of mathematical modelling of infectious disease diffusion by simultaneously investigating the underlying microscopic dynamics in terms of percolation models, effective description via compartmental models and the employment of temporal symmetries naturally encoded in the mathematical language of critical phenomena. Our report reviews these approaches and determines their common denominators, relevant for theoretical epidemiology and its link to important concepts in theoretical physics. We show that the different frameworks exhibit common features such as criticality and self-similarity under time rescaling. These features are naturally encoded within the unifying field theoretical approach. The latter leads to an efficient description of the time evolution of the disease via a framework in which (near) time-dilation invariance is explicitly realised. As important test of the relevance of symmetries we show how to mathematically account for observed phenomena such as multi-wave dynamics. The models presented here are of immediate relevance for different realms of scientific enquiry from medical applications to the understanding of human behaviour. Our review offers novel perspectives on how to model, capture, organise and understand epidemiological data and disease dynamics for modelling real-world phenomena.

read more

Citations
More filters
Posted ContentDOI

Variant-driven multi-wave pattern of COVID-19 via Machine Learning clustering of spike protein mutations

TL;DR: In this article, a machine learning algorithm yielding a temporal clustering of the available dataset was designed to identify and define emerging persistent variants that are in agreement with known evidences and to highlight emerging variants of epidemiological interest as branching events that occur over time.
Journal ArticleDOI

The mathematics of multiple lockdowns.

Antonio Scala
- 13 Apr 2021 - 
TL;DR: In this article, the authors explore the impact of lockdown strategies on the evolution of an epidemic and show that repeated lockdowns have a beneficial effect, reducing the final size of the infection, and that they represent a possible support strategy to vaccination policies.
Posted Content

Epidemiological theory of virus variants

TL;DR: In this paper, the authors propose a physical theory underlying the temporal evolution of competing virus variants that relies on the existence of (quasi) fixed points capturing the large time scale invariance of the dynamics.
Posted Content

Variant-driven multi-wave pattern of COVID-19 via a Machine Learning analysis of spike protein mutations.

TL;DR: In this paper, the temporal variability of the Spike protein sequence has been used to identify, classify and track emerging virus variants, which can be used as an early warning system for the emergence of new persistent variants that may pose a threat of triggering a new wave of COVID-19.
Posted ContentDOI

Effective Mathematical Modelling of Health Passes During a Pandemic

TL;DR: In this article, the authors study the impact on the epidemiological dynamics of a class of restrictive measures that are aimed at reducing the number of contacts of individuals who have a higher risk of being infected with a transmittable disease.
References
More filters
Journal ArticleDOI

Path integral approach to birth-death processes on a lattice

TL;DR: In this article, the Fock space formalism for classical objects was cast in a path integral form and applied to general birth-death processes on a lattice, and the introduction of suitable auxiliary variables allowed one to formulate random walks with memory and irreversible aggregation processes in a Markovian way, which is treatable in this formalism.
Journal ArticleDOI

Pulse vaccination strategy in the SIR epidemic model

TL;DR: Theoretical results show that the measles ‘pulse’ vaccination strategy can be distinguished from the conventional strategies in leading to disease eradication at relatively low values of vaccination.
Journal ArticleDOI

Seasonal infectious disease epidemiology

TL;DR: The causes and consequences of seasonality are examined, and several new results concerning vaccination strategy and the interpretation of disease outbreak data are derived, and a mathematical analysis of routine and pulse vaccination programmes for seasonal infections is presented.
Journal ArticleDOI

A brief history of R0 and a recipe for its calculation.

TL;DR: Today, R0 is a more fully developed adult in epidemiology than in demography, and an algorithm for its calculation in heterogeneous populations is given.
Journal ArticleDOI

Stochastic theory of diffusion-controlled reaction

M Doi
- 01 Sep 1976 - 
TL;DR: A stochastic theory of a diffusion-controlled reaction is developed with the emphasis on the many-body aspects which rigorous Stochastic theories inevitably encounter as mentioned in this paper, and the classical Smoluchowski theory is shown to be strictly valid in the long-time scale.
Related Papers (5)