Journal ArticleDOI
The hepatocellular metabolism of 4-hydroxynonenal by alcohol dehydrogenase, aldehyde dehydrogenase, and glutathione S-transferase.
TLDR
The quantitative and dynamic importance of oxidative, reductive, and nonoxidative routes in the metabolism and detoxification of 4-HNE is described.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1995-01-01. It has received 236 citations till now. The article focuses on the topics: Aldehyde dehydrogenase & Metabolite.read more
Citations
More filters
Journal ArticleDOI
Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health.
TL;DR: The human health risks from clinical and animal research studies are reviewed, including aldehydes as haptens in allergenic hypersensitivity diseases, respiratory allergies, and idiosyncratic drug toxicity; the potential carcinogenic risks of the carbonyl body burden.
Journal ArticleDOI
Aldehyde Dehydrogenases in Cellular Responses to Oxidative/electrophilic Stress
Surendra Singh,Chad Brocker,Vindhya Koppaka,Ying Chen,Brian C. Jackson,Akiko Matsumoto,David C. Thompson,Vasilis Vasiliou +7 more
TL;DR: The ALDH superfamily represents a fundamentally important class of enzymes that contributes significantly to the management of electrophilic/oxidative stress within living systems and is associated with a variety of pathological conditions in humans.
Journal ArticleDOI
Reactions of 4-hydroxynonenal with proteins and cellular targets.
TL;DR: In vitro and in vivo production of 4HNE in response to pro-oxidant exposure has been demonstrated using antibodies to protein adducts of the lipid aldehyde, suggesting a role for protein modification by 4H NE in the pathogenesis of several diseases.
Journal ArticleDOI
4-hydroxynonenal: a membrane lipid oxidation product of medicinal interest.
TL;DR: The actual knowledge of HNE reactivity, metabolism, signaling and modulatory effect in the various human organs should provide a solid background to the investigation of the aldehyde's contribution to the pathogenesis of human major chronic diseases and would likely promote advanced and oriented applications not only in diagnosis and prevention but also in molecular treatment of human diseases.
Journal ArticleDOI
Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts
TL;DR: This commentary summarizes the data from the chemical and biochemical studies that provide support for the hypothesis that lipid peroxidation is involved in the endogenous formation of these exocyclic adducts.