Journal ArticleDOI
4-Hydroxyalk-2-enals are substrates for glutathione transferase
TLDR
It is proposed that a major biological function of the glutathione transferases is to protect the cell against products of oxidative metabolism, such as epoxides, organic hydroperoxide, and 4‐hydroxyalkenals.About:
This article is published in FEBS Letters.The article was published on 1985-01-07. It has received 401 citations till now. The article focuses on the topics: Glutathione reductase & GPX4.read more
Citations
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Journal ArticleDOI
Glutathione transferases--structure and catalytic activity.
Bengt Mannervik,U H Danielson +1 more
TL;DR: The glutathione transferases are recognized as important catalysts in the biotransformation of xenobiotics, including drugs as well as environmental pollutants, and numerous transferases from mammalian tissues, insects, and plants have been isolated and characterized.
Journal ArticleDOI
Mechanisms of carbon tetrachloride toxicity
TL;DR: Le CCl 4 provoque une degenerescence lipidique et une necrose centrolobulaire du foie dans la peroxydation lipidique and les troubles hepatocellulaires de l'homeostase du calcium.
Journal ArticleDOI
Superoxide and hydrogen peroxide in relation to mammalian cell proliferation
TL;DR: A wide variety of normal and malignant cell types generate and release superoxide or hydrogen peroxide in vitro either in response to specific cytokine/growth factor stimulus or constitutively in the case of tumour cells.
Journal ArticleDOI
Free radical-lipid interactions and their pathological consequences.
TL;DR: In this review, atherosclerosis and cancer have been addressed and the current thinking on the consequences for lipids of their interactions with free radicals and the pathological implications are presented.
References
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Journal ArticleDOI
Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver.
TL;DR: The activities of some glutathione-metabolizing enzymes were observed to be 5-to 60-fold lower in lung tissue than in the liver, and that phenobarbital nor methylcholanthrene had a significant effect on the levels of reduced glutATHione in lung and liver.
Book ChapterDOI
Assays for differentiation of glutathione S-transferases.
TL;DR: This chapter provides the spectrophotometric, titrimetric, nitrite, and cyanide assay for the differentiation of glutathione S-transferases.
Journal ArticleDOI
Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids☆
TL;DR: Investigations suggest that as compared to 4-hydroxynonenal very low amounts of other 4-Hydroxyalkenals are formed by actively peroxidizing liver microsomes, and this finding may help to elucidate the mechanism by which lipid peroxidation causes deleterious effects on cells and cell constituents.
Journal ArticleDOI
Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe2+ in rat liver microsomes.
TL;DR: It is concluded that considerable amounts of biologically reactive carbonyl derivatives are released in lipid peroxidation and yet may not be picked up by the thiobarbituric acid reaction.
Related Papers (5)
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.
John D. Hayes,David J. Pulford +1 more