The influence of anaesthesia and surgery on plasma cortisol, insulin and free fatty acids
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TLDR
The plasma cortisol level of patients anaesthetized for 1 hour with thiopentone and nitrous oxide was found to remain unchanged during body surface surgery, and during intra-abdominal surgery it rose to more than double the resting value.Abstract:
SUMMARY The plasma cortisol level of patients anaesthetized for 1 hour with thiopentone and nitrous oxide was found to remain unchanged. During body surface surgery it rose slightly, and during intra-abdominal surgery it rose to more than double the resting value. The blood sugar under the same circumstances changed in a qualitatively similar manner and the free fatty acids appeared to fall during anaesthesia without surgery, changed little during body surface surgery, and rose during intra-abdominal surgery. Plasma insulin during both types of surgery showed no significant change.read more
Citations
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Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes : a systematic overview
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General stress response to conventional and laparoscopic cholecystectomy.
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Endocrine and metabolic changes during surgery: anaesthetic implications
C. Traynor,George M. Hall +1 more
TL;DR: There is a vast and often conflicting literature on the hormonal and metabolic response to surgery and the necessary background information is provided to enable the results described in more detailed studies to be readily interpreted.
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Stimulation of Insulin Secretion by Long-Chain Free Fatty Acids. A DIRECT PANCREATIC EFFECT
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References
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The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
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Some effects of anaesthesia and surgery on carbohydrate and fat metabolism
TL;DR: The emotional stress of being brought to the operating theatre and the stress of surgery seem to be more important than anaesthesia in causing a rise in blood sugar and plasma FFA and a corresponding fall in levels of plasma insulin.
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Photometric adaptation of dole's microdetermination of free fatty acids.
TL;DR: The method is based on the measurement of color changes in phenol red barbital buffer in heptane-ethanol and has been applied to human serum and to incubation media containing fatty acids liberated from rat epididymal adipose tissue.
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The hyperglycaemic response to different types of surgery and anaesthesia
TL;DR: In patients anaesthetized primarily with thiopentone there was no significant rise without surgery and the rise was, in general, proportional to the stress of surgery, the largest being during intra-abdominal operations.