Open AccessJournal Article
The influence of estrogen on monoamine oxidase activity.
Reads0
Chats0
TLDR
Possible implications of the effects of estrogens on MAO activity are discussed, and the regulation of MAO is multifactorial, and there is evidence that it involves estrogens.Abstract:
The enzyme monoamine oxidase (MAO) has generated considerable interest as a biological marker. The serendipitous discovery that iproniazid was a weak MAO inhibitor (MAOI) led to the development and widespread use of MAOIs as antidepressants in the early 1950s. The-discovery of the two isoenzymes of MAO has led to the development of selective MAOIs that may have a more favorable side-effect profile. The regulation of MAO is multifactorial, and there is evidence that it involves estrogens. Improvement in mood and cognition reported in women on estrogen replacement therapy may also involve changes in MAO activity. The literature in this regard is reviewed here, and possible implications of the effects of estrogens on MAO activity are discussed.read more
Citations
More filters
Journal ArticleDOI
The ABCs of depression: integrating affective, biological, and cognitive models to explain the emergence of the gender difference in depression.
TL;DR: A model is proposed that integrates affective, biological, and cognitive factors as vulnerabilities to depression that heighten girls' rates of depression beginning in adolescence and account for the gender difference in depression.
Journal ArticleDOI
MAOA and the neurogenetic architecture of human aggression.
TL;DR: This work proposes that the MAOA-L, by causing an ontogenic excess of 5-hydroxytryptamine, labilizes critical neural circuitry for social evaluation and emotion regulation (the 'socioaffective scaffold'), thereby amplifying the effects of adverse early-life experience and creating deleterious sociocognitive biases.
Journal ArticleDOI
Neuroticism, major depression and gender: a population-based twin study.
TL;DR: The best-fitting model failed to establish a significant sex difference in the genetic correlation between N and MD, as well as evidence for sex-specific genetic factors for both traits, have implications for the diagnosis, classification, and treatment of the affective disorders, and molecular genetic approaches to the study of these traits.
Journal ArticleDOI
The etiology, biology, and evolving pathology of premenstrual syndromes
TL;DR: Direct directions for clinically-relevant progress include identification of specific subgroups of menstrually-related syndromes, assessment of the genetic vulnerability and changes in vulnerability along the life cycle, the diversified mechanisms by which vulnerability is translated into pathophysiology and symptoms, the normalization process as well as syndrome-based and etiology-based clinical trials.
Journal ArticleDOI
To what extent do oral contraceptives influence mood and affect
TL;DR: Compared to non-users, OC users experience less variability in affect across the entire menstrual cycle, and less negative affect during menstruation (i.e. withdrawal bleeding).