The influence of the site of infection on the immune response to group A streptococci.
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The findings suggest that in contrast to infection of the URT antibody response to streptolysin O is relatively feeble after streptococcal infection which is limited to the skin.Abstract:
The immune response after streptococcal infection of the skin and of the upper respiratory tract (URT) was studied prospectively in a group of normal children, ages 3-6 yr. The children were examined and cultures for group A streptococci were obtained weekly from the throat, nose, and skin lesions (when present). Paired sera were collected at the beginning and end of the study, and the changes in antibody titers were measured for three different streptococcal antigens: streptolysin O, deoxyribonuclease B (DNAse B), and nicotinamide adenine dinucleotidase (NADase).
The findings suggest that in contrast to infection of the URT antibody response to streptolysin O is relatively feeble after streptococcal infection which is limited to the skin. The response to NADase is also poor after cutaneous infection. Antibody responses to DNAse B are generally good regardless of the site of the infection. These and other studies indicate that anti-DNAse B is the antibody of choice in studying streptococcal infection of the skin and its complications.read more
Citations
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Journal ArticleDOI
Practice Guidelines for the Diagnosis and Management of Skin and Soft-Tissue Infections
Dennis L. Stevens,Alan L. Bisno,Henry F. Chambers,Henry F. Chambers,E. Dale Everett,Patchen Dellinger,Ellie J. C. Goldstein,Sherwood L. Gorbach,Jan V. Hirschmann,Jan V. Hirschmann,Edward L. Kaplan,Jose G. Montoya,Jose G. Montoya,Jose G. Montoya,James C. Wade +14 more
TL;DR: It is the recommendation of this committee that patients with soft-tissue infection be distinguished by signs and symptoms of systemic toxicity (e.g., fever or hypothermia, tachycardia [heart rate,] and so on).
Journal ArticleDOI
Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America
Dennis L. Stevens,Alan L. Bisno,Henry F. Chambers,E. Patchen Dellinger,Ellie J. C. Goldstein,Sherwood L. Gorbach,Jan V. Hirschmann,Sheldon L. Kaplan,Jose G. Montoya,James C. Wade,R. M. Alden +10 more
TL;DR: This guideline addresses the wide array of SSTIs that occur in this population and emphasizes the importance of clinical skills in promptly diagnosing SSTI, identifying the pathogen, and administering effective treatments in a timely fashion.
Journal ArticleDOI
Streptococcal Infections of Skin and Soft Tissues
Alan L. Bisno,Dennis L. Stevens +1 more
TL;DR: The recent resurgence of invasive group A streptococcal infections is a reminder that the pathogen can cause a variety of skin and soft-tissue infections, some of which are severe and even life-threatening.
Book ChapterDOI
Labor und Diagnose
H. Heimpel,K. Becker,G. Peters,Heike Freidank,H. Hartmann,E. Windler,R. Ferlinz,J. Schlegel,E. Samson,Bettina Wedi,Alexander Kapp,M. Tepel,G. Geserick,P. E. Petrides +13 more
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Acute rheumatic fever: a chink in the chain that links the heart to the throat?
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References
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Journal ArticleDOI
A serological differentiation of human and other groups of hemolytic streptococci.
TL;DR: Five strains of hemolytic streptococci isolated from man, other animals, milk, and cheese have been classified into five groups, which bear a definite relationship to the sources of the cultures, each being chemically distinct and ser specific in the individual groups.
Journal ArticleDOI
Typing group a hemolytic streptococci by m precipitin reactions in capillary pipettes.
TL;DR: A method is described for performing type-specific anti-M precipitin tests on group A hemolytic streptococci in 1 mm. capillary pipettes that now seems to be practical.
Journal ArticleDOI
Relationship of immune response to group A streptococci to the course of acute, chronic and recurrent rheumatic fever
TL;DR: A high initial titer of either antistreptolysin O, antistraptokinase or antihyaluronidase was found in the sera of 95 per cent of patients who could be studied within the first two months of onset of the rheumatic attack.
Journal ArticleDOI
Evaluation of the streptococcal desoxyribo-nuclease b and diphosphopyridine nucleotidase antibody tests in acute rheumatic fever and acute glomerulonephritis
TL;DR: These two new anti-body tests are particularly useful in providing evidence of a preceding streptococcal infection in those patients with manifestations of acute rheumatic fever or acute nephritis who fail to show an elevated ASO titer.