Journal ArticleDOI
The management of glucocorticoid deficiency: Current and future perspectives.
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TLDR
The prevention of adrenal crisis must be balanced with avoidance of the long-term adverse effects of over-replacement, and education and empowerment in the management of glucocorticoid deficiency, and the prevention of crises, are crucial.About:
This article is published in Clinica Chimica Acta.The article was published on 2020-03-05. It has received 13 citations till now. The article focuses on the topics: Glucocorticoid secretion & Glucocorticoid.read more
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Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia
Christopher M. Jones,Ashwini Mallappa,Nicole Reisch,Nikolaos Nikolaou,Nikolaos Nikolaou,Nils Krone,Nils Krone,Beverley Hughes,Donna M. O'Neil,Martin J. Whitaker,Jeremy W. Tomlinson,Karl-Heinz Storbeck,Deborah P. Merke,Richard J. Ross,Richard J. Ross,Wiebke Arlt,Wiebke Arlt +16 more
TL;DR: In this article, the authors quantify classic and alternative pathway-mediated androgen synthesis in CAH, their diurnal variation and their response to conventional glucocorticoid (GC) therapy and modified release hydrocortisone.
Journal ArticleDOI
Comorbidities of sarcoidosis
Claudio Tana,Marjolein Drent,Hilario Nunes,Vasilis Kouranos,Francesco Cinetto,Naomi T Jessurun,Paolo Spagnolo +6 more
TL;DR: In the diagnostic workup, a distinction must be made between sarcoidosis-related complaints and complaints caused by other separate disorders, because it can be very difficult to distinguish between complications of sarCOidosis and other concomitant conditions.
Dual-release hydrocortisone vs conventional glucocorticoids in adrenal insufficiency
TL;DR: DR-HC is associated with an improvement of metabolic parameters and cardiovascular risk compared to conventional GCs, which are associated with a worsening of these parameters, regardless of the dose used.
Journal ArticleDOI
Grapefruit Juice Facilitates Cortisol Replacement Therapy: Role of CYP3A Variant Alleles
TL;DR: Grapefruit juice enhances cortisol availability by increasing 11β-hydroxysteroid dehydrogenase (HSD) type 1 activity and simultaneously inhibiting cortisol metabolism by inhibiting the CYP3A enzymes.
Journal ArticleDOI
Glucocorticoid induced adrenal insufficiency
TL;DR: • Educate patients taking prednisolone ≥5 mg/day or equivalent for more than four weeks, 40 mg prednisolisolone for longer than one week, or repeated short courses of glucocorticoids via any route (≥3 per year) about the risk of glucocoorticoid induced adrenal insufficiency (GC-AI) as mentioned in this paper .
References
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Corticosteroid inhibition of ACTH secretion.
TL;DR: There is some evidence that suggests that whereas comparator elements are not reset during stress, a comparator element is reset during the course of the circadian rhythm so that different basal levels of steroid are achieved.
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Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline.
Stefan R. Bornstein,Bruno Allolio,Wiebke Arlt,Andreas Barthel,Andrew C. Don-Wauchope,Gary D. Hammer,Eystein S. Husebye,Deborah P Merke,M. Hassan Murad,Constantine A. Stratakis,David J. Torpy +10 more
TL;DR: A low diagnostic threshold in acutely ill patients, as well as in patients with predisposing factors, is suggested for pregnant women with unexplained persistent nausea, fatigue, and hypotension and a short corticotropin test is recommended as the "gold standard" diagnostic tool to establish the diagnosis.
Journal ArticleDOI
Corticosteroid insufficiency in acutely ill patients.
Mark S. Cooper,Paul M. Stewart +1 more
TL;DR: The authors present an updated, practical approach to the diagnosis and treatment of hypoadrenalism in acutely ill patients, and summarizes the physiology of the corticosteroid response in acute illness.
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Dehydroepiandrosterone replacement in women with adrenal insufficiency.
Wiebke Arlt,Frank Callies,J C van Vlijmen,Ines Koehler,Martin Reincke,Martin Bidlingmaier,Doris Dr Huebler,Michael Oettel,Michael Ernst,Heinrich M. Schulte,Bruno Allolio +10 more
TL;DR: Dehydroepiandrosterone improves well-being and sexuality in women with adrenal insufficiency and significantly improved overall well- being as well as scores for depression and anxiety.
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Use of oral corticosteroids in the United Kingdom
TL;DR: Investigation of the usage pattern of oral corticosteroids in a large sample representative of the general population in England and Wales found patients with arthropathies were most likely to use long-term, continuous treatment, and patients with chronic obstructive pulmonary disease least likely.