The natural history of prostatic cancer
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TLDR
The relevance of the marked variability and unpredictability in the natural history of prostatic cancer thus revealed to treatment decisions and interpretations of the results of treatment in the aging host are indicated.Abstract:
Various possibilities in the stage progression of prostatic carcinoma in the untreated host are supported by an analysis of pertinent literature. The relevance of the marked variability and unpredictability in the natural history of prostatic cancer thus revealed to treatment decisions and interpretations of the results of treatment in the aging host are indicated.read more
Citations
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Patterns of progression in prostate cancer.
John E. McNeal,RobertA. Kindrachuk,FuadS. Freiha,David G. Bostwick,EliseA. Redwine,ThomasA. Stamey +5 more
TL;DR: It was concluded that the natural history of prostate cancer is highly predictable and the capacity to metastasise probably develops only in tumours which have grown much larger than 1 ml and acquired poorly differentiated areas as a manifestation of the phenomenon of tumour progression.
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Clinical and biological significance of aneuploidy in human tumours.
TL;DR: The accumulating evidence that tumour ploidy reflects the biological behaviour of a large number of tumour types and that diploid tumours in particular have a relatively good prognosis is reviewed.
Journal ArticleDOI
The present status of radical prostatectomy for stages A and B prostatic cancer.
TL;DR: Radical prostatectomy for cure should be limited to clinical B1 cases without distant spread, but it provides the best 15-year survival rate more completely, more quickly, less expensively, and with fewer discomforts than other methods.
Journal ArticleDOI
Cancer volume and site of origin of adenocarcinoma in the prostate: relationship to local and distant spread.
TL;DR: Lymph node metastasis in radical prostatectomy cases was most strongly predicted by a combination of cancer volume plus percentage of high-grade tumor.
Journal ArticleDOI
Spread of prostatic cancer to bone.
TL;DR: The predilection of prostatic cancer to metastasize to bone has been recognized since Thompson’ reported the very first case and the mechanisms of this metastasis to bone and the response within bone will be emphasized.
References
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Journal ArticleDOI
Carcinoma of the prostate: Prognostic evaluation of certain pathologic features in 208 radical prostatectomies
David P. Byar,F. K. Mostofi +1 more
TL;DR: Evaluation of various factors affecting survival and mortality disclosed that an extension of the tumor to seminal vesicles or invasion of the capsule, whether detected clinically or pathologically, had an unfavorable prognosis while the side involved, the location of the tumors, and perineural invasion had no significant effect on the prognosis.
Journal ArticleDOI
Origin and development of carcinoma in the prostate
TL;DR: Detailed histologic study of 45 cancerous prostate glands in 134 autopsies provided new information on the natural history of prostatic carcinoma, suggesting a gradual increase in biologic malignant potential which is closely linked to tumor size.