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Journal ArticleDOI

Prediction of Prognosis for Prostatic Adenocarcinoma by Combined Histological Grading and Clinical Staging

Donald F. Gleason, +1 more
- 01 Jan 1974 - 
- Vol. 111, Iss: 1, pp 58-64
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TLDR
The data for stages III and IV patients with histologically low grade cancers suggest that these patients are at no greater risk of death from cancer than most stages I and II patients for whom radical prostatectomy has been recommended.
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This article is published in The Journal of Urology.The article was published on 1974-01-01. It has received 2029 citations till now. The article focuses on the topics: Grading (tumors) & Gleason grading system.

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EAU guidelines on prostate cancer

TL;DR: The guidelines have been updated and level of evidence/grade of recommendation added to the text enables readers to better understand the quality of the data forming the basis of the recommendations.
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The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System.

TL;DR: The basis for a new grading system was proposed in 2013 by one of the authors and accepted by the World Health Organization for the 2016 edition of Pathology and Genetics: Tumours of the Urinary System and Male Genital Organs.
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EAU Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent—Update 2013

TL;DR: Current evidence is insufficient to warrant widespread population-based screening by prostate-specific antigen (PSA) for PCa, and watchful waiting is a treatment alternative to androgen-deprivation therapy (ADT), with equivalent oncologic efficacy.
Journal ArticleDOI

Pathologic and clinical findings to predict tumor extent of nonpalpable (stage T1c) prostate cancer

TL;DR: Serum PSA level, PSA density, and needle biopsy pathologic findings are accurate predictors of tumor extent and it may be reasonable to follow up some patients whose tumors are most likely insignificant with serial PSA measurements and repeated biopsies.
References
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Estrogen treatment for cancer of the prostate. Early results with 3 doses of diethylstilbestrol and placebo

John C. Bailar, +1 more
- 01 Aug 1970 - 
TL;DR: The 1.0-mg dose has been as effective as the 5.0‐mg dose in controlling the prostate cancer, but it does not seem to be associated with the excess risk of cardiovascular death.
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