The Ph1 Locus Suppresses Cdk2-Type Activity during Premeiosis and Meiosis in Wheat
Emma Greer,Azahara C. Martín,Ali Pendle,Isabelle Colas,Alexandra M. E. Jones,Graham Moore,Peter Shaw +6 more
TLDR
This article examines the role of cyclin-dependent kinase (Cdk) activity in pairing of homoeologous chromosomes in wheat, finding that the Ph1 locus suppresses Cdk2-type activity, thus affecting replication and histone H1 phosphorylation.Abstract:
Despite possessing multiple sets of related (homoeologous) chromosomes, hexaploid wheat (Triticum aestivum) restricts pairing to just true homologs at meiosis. Deletion of a single major locus, Pairing homoeologous1 (Ph1), allows pairing of homoeologs. How can the same chromosomes be processed as homologs instead of being treated as nonhomologs? Ph1 was recently defined to a cluster of defective cyclin-dependent kinase (Cdk)-like genes showing some similarity to mammalian Cdk2. We reasoned that the cluster might suppress Cdk2-type activity and therefore affect replication and histone H1 phosphorylation. Our study does indeed reveal such effects, suggesting that Cdk2-type phosphorylation has a major role in determining chromosome specificity during meiosis.read more
Citations
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The molecular biology of meiosis in plants.
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Chromatin reprogramming during the somatic-to-reproductive cell fate transition in plants
Wenjing She,Daniel Grimanelli,Kinga Rutowicz,Marek W. J. Whitehead,Marcin Puzio,Maciej Kotliński,Andrzej Jerzmanowski,Célia Baroux +7 more
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Understanding and Manipulating Meiotic Recombination in Plants
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